Clinical relevance of increased serum preneoplastic antigen in hepatitis C-related hepatocellular carcinoma

Table 2 Sensitivity and specificity of preneoplastic antigen, α-fetoprotein, and des-γ-carboxy-prothrombin in patients with hepatitis C virus-related hepatocellular carcinoma

	(A) HCC vs hepatitis		(B) HCC vs hepatitis/cirrhosis
	Sensitivity (%)	Specificity (%)	Sensitivity (%)	Specificity (%)
PNA	63.8	78.0	63.8	66.0
AFP	61.7	88.0	61.7	75.5
DCP	61.7	94.0	61.7	83.0

The sensitivity and specificity of markers were determined to discriminate hepatocellular carcinoma patients from (A) hepatitis patients and (B) hepatitis and cirrhosis patients. The cut-off value for positivity was 5 ng/mL for preneoplastic antigen, 10 ng/mL for α-fetoprotein, and 40 mAU/mL for des-γ-carboxy-prothrombin. HCC: Hepatocellular carcinoma; PNA: Preneoplastic antigen; AFP: α-Fetoprotein; DCP: Des-γ-carboxy-prothrombin.