Single-nucleotide polymorphisms of HLA and Polygonum multiflorum-induced liver injury in the Han Chinese population

Table 5 Performance of the rs1055348 G allele for HLA-B*35:01 in the Polygonum multiflorum-induced liver injury group (n = 73) and the other drug-induced liver injury group (n = 78)

Group	TP	TN	FP	FN	Sensitivity (95%CI)	Specificity (95%CI)	PPV (95%CI)	NPV (95%CI)	κ (95%CI)
PM-DILI	60	84	2	0	100.0 (94.0-100.0)	97.7 (91.9-99.7)	96.8 (88.8-99.6)	100.0 (95.7-100.0)	0.959 (0.879-1.000)
Other-DILI	28	204	4	0	100.0 (87.7-100.0)	98.1 (95.1-99.5)	87.5 (71.0-96.5)	100.0 (98.2-100.0)	0.911 (0.825-0.996)

TP: True positive; TN: True negative; FP: False positive; FN: False negative; PPV: Positive predictive value; NPV: Negative predictive value; Other-DILI: Other drug-induced liver injury; PM-DILI: Polygonum multiflorum-induced liver injury; CI: Confidence interval.