Single-nucleotide polymorphisms of HLA and Polygonum multiflorum-induced liver injury in the Han Chinese population

Table 4 Biochemical characteristics between patients with the rs1055348 G allele and those without the rs1055348 G allele

Variables	PM-DILI				Other-DILI
	With the rs1055348 G allele (n = 58)	Without the rs1055348 G allele (n = 15)		P value	With the rs1055348 G allele (n = 32)	Without the rs1055348 G allele (n = 86)	P value
Age, mean ± SD, yr	46.7 ± 15.1	51.2 ± 16.2	0.317		49.2 ± 14.4	53.4 ± 14.0	0.152
Female, n (%)	42 (72.4)	14 (93.3)	0.167		22 (68.8)	52 (60.5)	0.408
BMI	23.7 ± 2.9	23.0 ± 3.0	0.407		23.8 ± 3.0	24.0 ± 3.9	0.774
Medication time1, d	30 (40.8)	30 (22)	0.533		46.5 (63.5)	30 (54)	0.269
ALT (U/L)	1234.8 ± 609.5	603.2 ± 517.0	< 0.0001		936.7 ± 866.7	510.8 ± 532.7	0.013
AST (U/L), n	876.9 ± 537.8 (51)	509.2 ± 507.6 (14)	0.025		712.8 ± 691.5 (32)	401.0 ± 513.4 (86)	0.009
ALP (U/L), n	155.8 ± 59.8 (48)	116.7 ± 40.0 (11)	0.044		140.3 ± 99.4 (28)	167.8 ± 240.8 (77)	0.559
TBil (mg/dL), n	123.9 ± 110.5 (48)	70.7 ± 84.9 (13)	0.113		85.7 ± 104.8 (29)	73.3 ± 87.4 (70)	0.547

¹A variable is expressed as the median (interquartile range). Variables are expressed as the mean ± SD. PM-DILI: Polygonum multiflorum-induced liver injury; Other-DILI: Other drug-induced liver injury; BMI: Body mass index; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALP: Alkaline phosphatase; Tbil: Total bilirubin level.