Single-nucleotide polymorphisms of HLA and Polygonum multiflorum-induced liver injury in the Han Chinese population

Table 3 Association between the 8 single-nucleotide polymorphisms and Polygonum multiflorum-induced liver injury

SNP ID	Chromose (Gene)	Minor allele	Minor allele frequency (%)			PM-DILI vs control		PM-DILI vs Other-DILI
			PM-DILI (n = 73)	Other-DILI (n = 118)	Control (n = 191)	P value	OR (95%CI)	P value	OR (95%CI)
rs1055348	6 (HLA-B)	G	42.5%	13.6%	8.6%	1.72 × 10-19a	13.62 (7.16-25.9)	1.84 × 10-10a	10.06 (5.06-20)
rs202047044	6 (HLA-DRB1)	C	22.9%	17.5%	8.1%	4.64 × 10-6a	4.1 (2.25-7.47)	0.212	1.53 (0.84-2.76)
rs111686806	6 (HLA-A)	T	27.2%	27.6%	11.6%	1.72 × 10-5a	3.96 (2.21-7.1)	0.937	0.97 (0.53-1.77)
rs2231119	6 (HLA-A)	A	26.0%	24.4%	36.8%	0.020	0.57 (0.36-0.90)	0.714	1.11 (0.66-1.85)
rs111534875	6 (HLA-DRB1)	A	29.6%	32.0%	20.1%	0.022	1.64 (1.06-2.55)	0.622	0.89 (0.57-1.40)
rs1042597	2 (UGT1A8)	G	42.1%	44.0%	51.0%	0.071	0.71 (0.48-1.04)	0.723	0.93 (0.61-1.41)
rs78246137	6 (HLA-DRB1)	T	29.5%	31.6%	22.5%	0.095	1.45 (0.94-2.25)	0.656	0.9 (0.57-1.43)
rs5747933	22 (PRODH)	T	13.6%	16.7%	10.2%	0.279	1.35 (0.77-2.39)	0.424	0.8 (0.45-1.42)

^aP value that reached the threshold of P < 6.25 × 10^-3 by Bonferroni correction. Other-DILI: Other drug-induced liver injury; SNP: Single-nucleotide polymorphisms; PM-DILI: Polygonum multiflorum-induced liver injury; OR: Odd ratio; CI: Confidence interval.