Single-nucleotide polymorphisms of HLA and Polygonum multiflorum-induced liver injury in the Han Chinese population

Table 2 Demographic and clinical features of Polygonum multiflorum-induced liver injury patients and other drug-induced liver injury patients

Characteristics	PM-DILI (n = 73)	Other-DILI (n = 118)	P
Mean age, yr	47.7 ± 15.8	52.3 ± 14.2	0.045
Female, n (%)	56 (76.7)	74 (62.7)	0.044
BMI	23.6 ± 3.2	24.0 ± 3.7	0.447
Medication time1, d	30 (45)	30 (60.8)	0.097
ALT (U/L)	1105.0 ± 679.9	626.3 ± 670.1	< 0.001
AST (U/L), n	797.7 ± 557.3 (65)	485.6 ± 596.5 (118)	0.001
ALP (U/L), n	148.5 ± 58.4 (59)	160.5 ± 212.3 (105)	0.673
TBil (mg/dL), n	112.9 ± 107.2 (61)	76.9 ± 92.5 (99)	0.026
Injury type	n = 59	n = 105	0.917
Hepatocellular	57	82
Cholestatic	1	12
Mixed	1	11
RUCAM score			0.319
3-5 (Possible)	7	20
6-8 (Probable)	53	82
≥ 9 (Highly probable)	13	16

¹A variable is expressed as the median (interquartile range). Other variables are expressed as the mean ± standard deviation (SD). BMI: Body mass index; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALP: Alkaline phosphatase; TBil: Total bilirubin level; RUCAM: Roussel Uclaf causality assessment method; Other-DILI: Other drug-induced liver injury; PM-DILI: Polygonum multiflorum-induced liver injury.