Single-nucleotide polymorphisms of HLA and Polygonum multiflorum-induced liver injury in the Han Chinese population

Table 1 Candidate single-nucleotide polymorphisms selected from whole-exome sequencing of 8 Polygonum multiflorum-induced liver injury patients and 8 healthy controls

SNP ID	Chromosome	Gene	Number of PM-DILI patients with candidate SNP	Number of healthy controls with candidate SNP
rs1042597	2	UGT1A8	6	0
rs37959583	2	DRC1	6	3
rs111686806	6	HLA-A	5	0
rs2231119	6	HLA-A	8	0
rs11369033	6	HLA-A	6	0
rs1156624013	6	HLA-A	6	0
rs1171629793	6	HLA-A	5	2
rs10595163	6	HLA-A	5	0
rs10503412	6	HLA-B	5	0
rs1055348	6	HLA-B	5	0
rs23086553	6	HLA-B	6	0
rs10504581	6	HLA-B	5	0
rs10514881	6	HLA-B	6	0
rs202047044	6	HLA-DRB1	4	0
rs111534875	6	HLA-DRB1	5	3
rs78246137	6	HLA-DRB1	7	0
rs23087683	6	HLA-DRB1	5	0
rs17999313	8	NAT2	4	0
rs5747933	22	PRODH	7	3

¹Single-nucleotide polymorphism (SNPs) detected in fewer than 95% of individuals (2 SNPs).

²SNPs with minor allele frequency < 5% (1 SNPs).

³SNPs with Hardy-Weinberg equilibrium test P values < 0.05 (8 SNPs). PM-DILI: Polygonum multiflorum-induced liver injury.