Importance of genetic polymorphisms in liver transplantation outcomes

Table 4 Genes and their single nucleotide polymorphisms investigated in association with hepatocellular carcinoma recurrence after liver transplantation

Ref.	Etiology/Population	Genes and best 95%CI OR	Key points
	N (non HCC/HCC)
Shi et al[53]	Various	Donor TLR 4: rs1927914 (1.886-12.5)1; Recipient TLR 4: rs1927914 NS	Donor TLR4 TT variant is an independent risk factor for HCC recurrence [OR 95%CI = 6.499 (1.799-23.481), after correction], and is associated with shorter recurrence free survival and overall survival
	Eastern Asian
	49/34
Zhang et al[52]	HBV	Recipient IL-15: rs10519613 (1.636–16.168), rs13122930 NS; Donor IL-15: rs10519613 NS; rs13122930 NS	Recipient IL-15 rs10519613 CA/AA genotype is an independent risk factor for shorter tumor free survival and overall survival after correcting for histologic grade, tumor thrombus, tumor stage and UCSF criteria
	Eastern Asian
	74/38
			OR 95 CI for tumor free survival = 2.214 (1.041–4.708), for overall survival = 3.152 (1.358–7.315)
de la Fuente et al[54]	Various	Recipient TLR9: rs187084 (0.01–0.87); rs5743836 – NS	TLR9 rs187084 TT genotype was associated with a decreased risk of HCC recurrence
	European
	139/20

¹Calculated from study data by authors of this review for dominant model. HBV: Hepatitis B virus; HCC: Hepatocellular carcinoma; IL: Interleukin; N: Number; NS: Not significant; OR: Odds ratio; TLR: Toll like receptor; UCSF: University of California San Francisco; 95%CI OR: 95% confidence interval for odds ratio.