Importance of genetic polymorphisms in liver transplantation outcomes

Table 2 Genes and their single nucleotide polymorphisms investigated in association with new-onset of diabetes mellitus after liver transplantation

Ref.	Etiology/Population	Genes and best 95%CI OR	Key points
	N (non-NODM/NODM)
Mottaghi et al[31]	Various	Recipient AGT: rs699 - 7.326 (2.0-26.8), rs4762 – NS	The presence of AGT rs699 T allele may significantly increase the NODM risk
	Iran
	62/53
Husen et al[25]	Various	Recipient Mtor: rs2295080 (1.48-23.4); rs12139042, rs2536 – NS	rs2295080 CC genotype is associated with a risk of DM on everolimus-based IS
	European
	115/121		DM was a secondary objective, with a very low N of DM patients
Cen et al[26]	Hepatitis C, HCC	Recipient ADIPOQ: rs1501299 (0.05-0.61)2, rs822396 (0.13-0.70)3; NS for recipient SNPs: ADIPOR2 rs767870, TLR4 rs1927907, CCL5 rs2107538 and rs2280789, CYP3A5 rs776746, PPARA rs4823613, ACE rs4291, HSD11B1 rs4844880, KCNJ11 rs5219, KCNQ1 rs2237892	ADIPOQ rs1501299 and rs822396 are associated with a risk of NODM
	China
	181/75		rs1501299 is an independent risk factor
Zhang et al[28]	Various	Recipients SUMO4: rs237025 (1.42-5.91); Donors SUMO4: rs237025 (1.542–9.007)	Donor and recipient rs237025 G allele and their combination were independent predictive factors for NODM
	China
	102/24

¹In the cited article the N of non-diabetic patients is wrongly stated to be 127, which is a total N.

²Calculated from study data for codominant model by authors of this review.

³Calculated from study data for dominant model by authors of this review. ACE: Angiotensin I converting enzyme; ADIPOQ: Adiponectin, C1Q and collagen domain containing; ADIPOR2: Adiponectin receptor 2; AGT: Angiotensinogen; CCL5: Chemokine (C-C motif) ligand 5; CYP: Cytochrome P450; DM: Diabetes mellitus; HCC: Hepatocellular carcinoma; HSD11B1: Hydroxysteroid 11-beta dehydrogenase 1; IS: Immunosuppression; KCNJ11: Potassium inwardly-rectifying channel, subfamily J, member 11; KCNQ1: Potassium voltage-gated channel, KQT: Like subfamily, member 1; mTOR: Mammalian target of rapamycin; N: Number; NODM: New-onset diabetes mellitus; NS: Not significant; PPARA: Peroxisome proliferator-activated receptor alpha; SNP: Single nucleotide polymorphism; SUMO4: Small ubiquitin like modifier 4; TLR4: Toll like receptor 4; 95%CI OR: 95% confidence interval for odds ratio.