Importance of genetic polymorphisms in liver transplantation outcomes

Table 1 Genes and their single nucleotide polymorphisms investigated in association with acute cellular rejection after liver transplantation

Ref.	Etiology/Population	Genes and best 95%CI OR	Key points
	N (non-ACR/ACR)
Yu et al[13]	Various	Recipient CD276: rs2127015 (0.05-0.93); NS for: rs11072431, rs11574495, rs12593558, rs12594627, rs3816661 rs7176654; Recipient TREML2: rs4714431, rs6915083, rs7754593, rs9394767 NS1	Recipient's CD276 (rs2127015) T allele is weakly associated with ACR and with CD276 mRNA expression
	Eastern Asian
	334/54
Ostojic et al[14]	Alcoholic	Recipient CXCL9: rs10336 NS; Recipient CXCL10: rs3921 NS	No association found. CXCL9 (rs10336) is associated with earlier ACR occurrence and higher plasma CXCL9 concentrations
	European
	156/59
Sun et al[12]	Various	Recipient IL-17: rs2275913 (0.07-0.77)2	Associated with increased IL-17 plasma concentration and with cyclosporine metabolism (CYP3A4 and CYP3A5 expression)
	Eastern Asian
	66/40
Verma et al[16]	Various	Recipient FOXP3: rs3761547, rs3761548, and rs2232365 NS	Association found only in a very small subgroup of steroid resistant ACR patients (N = 5) for rs3761548
	Asian
	86/16
			Associated with the degree of mixed lymphocyte reaction
Thude et al[15]	Various	Recipient KLRB1: rs1135816 NS	No association found
	European
	163/178
Thude et al[8]	Various	Recipient HPA-3 a/b: rs5910 (1.749–41.8); Recipient/donor incompatibility: rs5910 (1.78–7.39); HPA-1, -2, -3, -5, -15 NS for all	HPA-3 incompatibility and HPA-3 b/b genotype were associated with higher incidence of ACR
	European
	53/43
			There was no difference in the time of ACR occurrence
Fereidooni et al[10]	Various	Recipient IL28B: rs12979860 NS	No association found
	Western Asian
	101/39
Valero-Hervás et al[11]	Various	Recipient C3 complement rs2230199 (0.09-0.77)	C3FF genotype is associated with lower incidence of ACR, independently after multivariate analysis for sex, HCV infection, therapy and donor type
	European
	277/185

¹Although a statistical significance for rs6915083 and rs7754593 of TREML2 is noted in the manuscript, the 95% ORs include 1 and should not be considered a significant association.

²Calculated from study data by authors of this review. ACR: Acute cellular rejection; C3: Complement component 3; CD: Cluster of differentiation; CXCL: Chemokine (C‐X‐C motif) ligand; CYP: Cytochrome P450; FOXP3: Forkhead box P3; HCV: Hepatitis C virus; HPA: Human platelet antigen; IL: Interleukin; KLRB1: Killer cell lectin-like receptor B1; mRNA: messenger ribonucleic acid; N: Number; NS: Not significant; TREML2: Triggering receptor expressed on myeloid cell‐like transcript 2; 95%CI OR: 95% confidence interval for odds ratio.