Copyright
©The Author(s) 2020.
World J Gastroenterol. Mar 21, 2020; 26(11): 1113-1127
Published online Mar 21, 2020. doi: 10.3748/wjg.v26.i11.1113
Published online Mar 21, 2020. doi: 10.3748/wjg.v26.i11.1113
Circulating microRNA | microRNA regulation | Clinical significance in HBV infection | Ref. |
miR-122 | ↑ | Correlates with the necroinflammatory activity, HBsAg and HBV DNA; Also correlated with ≥ F2 stage of liver fibrosis | Waidmann et al[103], Ji et al[109], Wang et al[106] |
miR-210 | ↑ | Marker of necroinflammation; Varies with the severity of HBV hepatitis | Song et al[140] |
miR-125 (-125a-5p/ -125b) | ↑ | Correlates with HBV intrahepatic replication and necroinflammatory activity | Li et al[141], Zheng et al[134] |
miR-124 | ↑ | Marker of HBV-associated necroinflammation | Wang et al[142] |
miR-29 | ↓ | Marker of liver fibrosis irrespective of aetiology | Xing et al[139] |
miR-223 | ↓ | Marker of liver fibrosis, decreases with the progression to cirrhosis | Bao et al[43] |
miR-185 | ↑ | Increases in advanced HBV fibrosis; Could play a therapeutic role in HBV gene suppression in tumoral cells | Li et al[136], Fan et al[143] |
- Citation: Iacob DG, Rosca A, Ruta SM. Circulating microRNAs as non-invasive biomarkers for hepatitis B virus liver fibrosis. World J Gastroenterol 2020; 26(11): 1113-1127
- URL: https://www.wjgnet.com/1007-9327/full/v26/i11/1113.htm
- DOI: https://dx.doi.org/10.3748/wjg.v26.i11.1113