Review
Copyright ©The Author(s) 2020.
World J Gastroenterol. Mar 21, 2020; 26(11): 1113-1127
Published online Mar 21, 2020. doi: 10.3748/wjg.v26.i11.1113
Table 4 Circulating microRNAs in hepatitis B virus infection and their role in necroinflammation vs fibrosis
Circulating microRNAmicroRNA regulationClinical significance in HBV infectionRef.
miR-122Correlates with the necroinflammatory activity, HBsAg and HBV DNA; Also correlated with ≥ F2 stage of liver fibrosisWaidmann et al[103], Ji et al[109], Wang et al[106]
miR-210Marker of necroinflammation; Varies with the severity of HBV hepatitisSong et al[140]
miR-125 (-125a-5p/ -125b)Correlates with HBV intrahepatic replication and necroinflammatory activityLi et al[141], Zheng et al[134]
miR-124Marker of HBV-associated necroinflammationWang et al[142]
miR-29Marker of liver fibrosis irrespective of aetiologyXing et al[139]
miR-223Marker of liver fibrosis, decreases with the progression to cirrhosisBao et al[43]
miR-185Increases in advanced HBV fibrosis; Could play a therapeutic role in HBV gene suppression in tumoral cellsLi et al[136], Fan et al[143]