Circulating microRNAs as non-invasive biomarkers for hepatitis B virus liver fibrosis

Table 1 Circulating and intrahepatic microRNA regulation and target processes involved in liver fibrogenesis in hepatitis B virus infection

MicroRNA	Plasma level	Liver tissue	Mediated processes involved in liver fibrosis	Ref.
miR-34a	↑	↑	Cell-cycle regulator (cell differentiation, proliferation, metabolism, apoptosis); HSC activation	Guo et al[45]; Singh et al[42]
miR-221 miR-222	↑	↑	Collagen synthesis; HSC proliferation; Liver fibrosis; Oncogenesis	Singh et al[42]
miR 27a/b	↑	↑	HSC activation, differentiation and proliferation	Zhang et al[131]
miR 181a/b	↑	↑	Cell cycle regulator; HSC activation and proliferation	Yu et al[132]
miR 199a/b	↓	↑	HSC activation	Murakami et al[91]
miR-223	↓; ↓ EVs	↑	Inflammatory response	Akamatsu et al[133]; Bao et al[43]; Ye et al[59]; Wang et al [106]
miR-125 (-125a-5p/ -125b)	↑	↑	HSC activation, proliferation	Zheng et al[134]; You et al[49]
miR 21-5p	↑in total plasma; ↓ in EVs	↑	Collagen synthesis; Oncogenesis	Bao et al[43]; Wei et al[68]; Wang et al[135]

↑ means upregulation. ↓ means downregulation. EVs: Extracellular vesicles; HSC: Hepatic stellate cell; MiR: MicroRNA.