Serum N-glycan markers for diagnosing liver fibrosis induced by hepatitis B virus

Table 4 Predictive value of fibrosis diagnostic models in the modeling group

Fibrosis stage	Model	Cutoff value	Sen	Spec	PPV	NPV	AUROC
F0-F1 vs F2-F4	Model A	0.8032	0.871	0.839	0.951	0.642	0.890
	GlycoFibroTest	-0.4404	0.280	0.903	0.913	0.257	0.538
	GlycoCirrhoTest	-0.2946	0.778	0.452	0.837	0.359	0.644
	APRI	0.4871	0.626	0.839	0.933	0.385	0.790
	FIB-4	0.4720	0.401	0.855	0.908	0.285	0.599
	S index	0.0543	0.742	0.596	0.871	0.386	0.701
	Model A + ALT + PLT	0.7779	0.923	0.806	0.945	0.746	0.912
F0-F2 vs F3-F4	Model B	0.3418	0.986	0.514	0.662	0.974	0.752
	GlycoFibroTest	-0.2295	0.128	1.000	1.000	0.543	0.524
	GlycoCirrhoTest	0.0033	0.270	0.911	0.745	0.564	0.618
	APRI	0.3964	0.819	0.562	0.638	0.766	0.740
	FIB-4	0.3930	0.609	0.726	0.677	0.663	0.699
	S index	0.0890	0.664	0.711	0.690	0.686	0.738
	Model B + ALT + PLT	0.4404	0.855	0.685	0.720	0.833	0.829
F0-F3 vs F4	Model C	0.2258	0.808	0.598	0.407	0.901	0.747
	GlycoFibroTest	-0.3200	0.274	0.939	0.606	0.791	0.571
	GlycoCirrhoTest	-0.0287	0.356	0.827	0.413	0.790	0.607
	APRI	0.4206	0.859	0.488	0.359	0.912	0.666
	FIB-4	0.3762	0.831	0.657	0.447	0.921	0.795
	S index	0.0817	0.765	0.571	0.380	0.876	0.717
	Model C + ALT + PLT	0.3010	0.789	0.845	0.629	0.923	0.885

F¹ APRI = [AST (IU/L) / 40] × 100/PLT (10⁹/L). F² FIB-4 = [age (yr) × AST (IU/L)] / [PLT (10⁹ /L) × ALT^1/2 (IU/L)]. F³ S index = 1000 × GGT (IU/L) / [PLT (10⁹/L) × ALB² (g/L)]. Sen: Sensitivity; Spec: Specificity; PPV: Positive predictive value; NPV: Negative predictive value; ALT: Alanine aminotransferase; GGT: γ-glutamyl-transpeptidase; PLT: Platelet; AUROC: Area under receiver operating characteristic curves.