Serum N-glycan markers for diagnosing liver fibrosis induced by hepatitis B virus

Table 3 N-glycome profiling results in hepatitis B virus-infected patients with liver fibrosis F0-F4 and differences between different fibrosis stages in the modeling group (mean ± SD)

Peak	F0-F1	F2	F3	F4	F0-F1 vs F2-F4	F0-F2 vs F3-F4	F0-F3 vs F4
1	5.92 ± 1.46	7.62 ± 2.57	7.51 ± 2.09	8.68 ± 3.60	< 0.001c	< 0.001c	< 0.001c
2	1.95 ± 0.67	1.78 ± 0.76	1.60 ± 0.57	1.85 ± 0.76	0.161	0.235	0.312
3	4.57 ± 1.16	5.96 ± 1.43	6.04 ± 1.17	6.21 ± 1.66	< 0.001c	< 0.001c	0.003b
4	7.34 ± 1.37	5.96 ± 1.15	5.54 ± 0.81	5.43 ± 0.81	< 0.001c	< 0.001c	< 0.001c
5	47.90 ± 3.77	46.93 ± 4.64	46.75 ± 4.59	46.27 ± 6.23	0.097	0.163	0.197
6	16.89 ± 2.92	17.66 ± 3.01	18.13 ± 2.89	17.30 ± 2.58	0.086	0.323	0.413
7	4.48 ± 1.08	4.53 ± 0.95	4.86 ± 1.22	4.90 ± 1.16	0.089	0.004b	0.058
8	8.07 ± 2.07	6.91 ± 1.90	6.74 ± 1.70	6.22 ± 2.16	< 0.001c	< 0.001c	0.001b
9	2.87 ± 1.27	2.65 ± 1.01	2.82 ± 1.12	3.12 ± 1.33	0.684	0.136	0.035a

^aP < 0.05.

^bP < 0.01.

^cP < 0.001.