Prognostic factors and predictors of postoperative adjuvant transcatheter arterial chemoembolization benefit in patients with resected hepatocellular carcinoma

Table 2 Prognostic factors for overall survival based on univariate analysis of the matched data

	PA-TACE			Surgery alone
Characteristic	Hazard ratio	95%CI	P value	Hazard ratio	95%CI	P value
Age (yr)			0.043			0.166
< 65	Reference			Reference
≥ 65	0.300	0.093-0.963	0.043	1.490	0.848-2.619	0.166
Gender			0.578			0.001
Male	Reference			Reference
Female	0.785	0.334-1.844	0.578	0.382	0.217-0674	0.001
BMI			0.187			0.121
< 23	Reference			Reference
23-25	0.497	0.233-1.060	0.070	0.859	0.525-1.407	0.546
≥ 25	0.912	0.476-1.747	0.781	0.517	0.275-0.971	0.040
BCLC stage			0.015			0.045
0	Reference			Reference
A	4.287	1.333-13.785	0.015	1.839	1.014-3.403	0.045
HBV			0.693			0.038
Negative	Reference			Reference
Positive	1.205	0.478-3.038	0.693	2.414	1.049-5.553	0.038
HCV			0.367			0.645
Negative	Reference			Reference
Positive	-	-		0	0.000-NA	0.963
Unknown	0.047	0-36.104	0.367	0.390	0.054-2.804	0.350
Cirrhosis			0.166			0.129
No	Reference			Reference
Yes	1.516	0.841-2.730	0.166	1.440	0.899-2.307	0.129
Family history			0.936			0.543
No	Reference			Reference
Yes	0.966	0.411-2.269	0.936	0.806	0.402-1.615	0.543
MVI			0.005			0.439
No	Reference			Reference
Yes	2.557	1.332-4.910	0.005	1.275	0.689-2.359	0.439
AFP (ng/mL)			0.429			0.416
≤ 200	Reference			Reference
> 200	1.255	0.715-2.203	0.429	1.203	0.771-1.878	0.416
ALBI grade			0.085			< 0.001
1	Reference			Reference
2	1.637	0.934-2.871	0.085	2.303	1.466-3.620	< 0.001
3	-	-	-	-	-	-
NLR			0.962			0.578
≤ Median	Reference			Reference
> Median	0.986	0.563-1729	0.962	0.881	0.564-1.376	0.578
Ferritin (ng/mL)			0.056			0.323
≤ 400	Reference			Reference
> 400	1.731	0.986-3.040	0.056	1.447	0.695-3.015	0.323
FHR			0.001			< 0.001
≤ Median	Reference			Reference
> Median	2.830	1.541-5.198	0.001	4.084	2.452-6.802	< 0.001
CRP (mg/L)			0.670			0.875
≤ 5	Reference			Reference
> 5	0.864	0.441-1.691	0.670	1.043	0.616-1.767	0.875
Times			0.193			-
1	Reference			-	-
2	0.661	0.319-1.370	0.266	-	-
3	2.171	0.668-7.059	0.197	-	-

PA-TACE: Postoperative adjuvant transcatheter arterial chemoembolization; BMI: Body mass index; BCLC: Barcelona Clinic Liver Cancer system; HBV: Hepatitis B virus; HCV: Hepatitis C virus; MVI: Microscopic vascular invasion; AFP: Alpha fetoprotein; ALBI: Albumin-bilirubin; NLR: Neutrophil-to-lymphocyte ratio; FHR: Ferritin-to-hemoglobin ratio; CRP: C-reactive protein; NA: Not available.