Prognostic factors and predictors of postoperative adjuvant transcatheter arterial chemoembolization benefit in patients with resected hepatocellular carcinoma

Table 1 Patient demographics and clinical characteristics, n (%)

	Original data			Matched data
Characteristic	PA-TACE	Surgery alone	P value	PA-TACE	Surgery alone	P value
Age (yr)			< 0.001			0.889
< 65	196 (73.0)	281 (66.0)		158 (83.6)	159 (84.1)
≥ 65	31 (13.7)	145 (34.0)		31 (16.4)	30 (15.9)
Gender			0.245			0.866
Male	197 (86.8)	355 (83.3)		170 (89.9)	169 (89.4)
Female	30 (13.2)	71 (16.7)		19 (10.1)	20 (10.6)
BMI			0.074			0.905
< 23	97 (42.7)	188 (44.1)		84 (44.4)	81 (42.9)
23-25	76 (33.5)	110 (25.8)		57 (30.2)	61 (32.3)
≥ 25	54 (23.8)	128 (30.0)		48 (25.4)	47 (24.9)
BCLC stage			0.509			0.614
0	43 (18.9)	90 (21.1)		38 (20.1)	42 (22.2)
A	184 (81.1)	336 (78.9)		151 (79.9)	147 (77.8)
HBV			< 0.001			0.362
Negative	25 (11.0)	101 (23.7)		22 (11.6)	28 (14.8)
Positive	202 (89.0)	325 (76.3)		167 (88.4)	161 (85.2)
HCV			0.282			0.351
Negative	218 (96.0)	402 (94.4)		183 (96.8)	182 (96.3)
Positive	3 (1.4)	3 (0.7)		0 (0)	2 (1.1)
Unknown	6 (2.6)	21 (4.9)		6 (3.2)	5 (2.6)
Cirrhosis			0.067			0.678
No	114 (50.2)	182 (42.7)		83 (43.9)	79 (41.8)
Yes	113 (49.8)	224 (57.3)		106 (56.1)	110 (58.2)
Family history			0.605			0.876
No	200 (88.1)	381 (89.4)		166 (87.8)	165 (87.3)
Yes	27 (11.9)	45 (10.6)		23 (12.2)	24 (12.7)
MVI			0.006			0.884
No	187 (82.4)	383 (89.9)		161 (85.2)	162 (85.7)
Yes	40 (17.6)	43 (10.1)		28 (14.8)	27 (14.3)
AFP (ng/mL)			< 0.001			1.000
≤ 200	96 (42.3)	252 (59.2)		96 (50.8)	96 (50.8)
> 200	131 (57.7)	174 (40.8)		93 (49.2)	93 (49.2)
ALBI grade			0.001			0.678
1	129 (56.8)	223 (52.3)		104 (55.0)	108 (57.1)
2	92 (40.5)	203 (47.7)		85 (45.0)	81 (42.9)
3	6 (2.6)	0 (0)		-	-
NLR			0.986			0.918
≤ Median	116 (51.1)	218 (51.2)		86 (45.5)	85 (45.0)
> Median	111 (48.9)	208 (48.8)		103 (54.5)	104 (55.0)
Ferritin (ng/mL)			0.196			0.914
≤ 400	147 (64.8)	297 (69.7)		125 (66.1)	124 (65.6)
> 400	80 (35.2)	129 (30.3)		64 (33.9)	65 (34.4)
FHR			0.095			0.918
≤ Median	114 (50.2)	243 (57.0)		98 (51.9)	97 (51.3)
> Median	113 (49.8)	183 (43.0)		91 (48.1)	92 (48.7)
CRP (mg/L)			0.089			0.341
≤ 5	176 (77.5)	304 (71.4)		138 (73.0)	146 (77.2)
> 5	51 (22.5)	122 (28.6)		51 (27.0)	43 (22.8)
Times			-			-
1	166 (73.1)	-		136 (71.9)	-
2	55 (24.2)	-		47 (24.9)	-
> 3	6 (2.7)	-		6 (3.2)	-

PA-TACE: Postoperative adjuvant transcatheter arterial chemoembolization; BMI: Body mass index; BCLC: Barcelona Clinic Liver Cancer system; HBV: Hepatitis B virus; HCV: Hepatitis C virus; MVI: Microscopic vascular invasion; AFP: Alpha fetoprotein; ALBI: Albumin-bilirubin; NLR: Neutrophil-to-lymphocyte ratio; FHR: Ferritin-to-hemoglobin ratio; CRP: C-reactive protein.