Synergistic protection of astragalus polysaccharides and matrine against ulcerative colitis and associated lung injury in rats

Figure 4 Astragalus polysaccharides combined with matrine inhibit the expression of zonula occludens-1 and Occludin in lung and colon tissues of rats with ulcerative colitis. A and B: Zonula occludens-1 (ZO-1) expression in colon (A) and lung tissues (B) in various groups detected by Western blot analysis; C and D: Occludin expression in colon (C) and lung tissues (D) in various groups detected by immunohistochemistry analysis. ^aP < 0.05 and ^bP < 0.01 vs normal group; ^cP < 0.05 and ^dP < 0.01 vs model group. APS: Astragalus polysaccharides; ZO-1: Zonula occludens-1; N: Normal group; M: Model group; SC: Salazopyrine control group; MT: Matrine treatment group; AT: Astragalus polysaccharides treatment group; MM: Monomer mixture group.