Usefulness of autotaxin for the complications of liver cirrhosis

Table 3 Correlation between autotaxin and clinical characteristics

Characteristics	Male		Female
	r	P value	r	P value
Serum biomarker
MELD-score	0.293	0.001	0.211	0.040
Fibrosis 4 index	0.470	< 0.001	0.335	< 0.001
APRI	0.438	0.001	0.414	< 0.001
ALBI	0.614	< 0.001	0.452	< 0.001
Clinical laboratory data
White blood cells	-0.123	0.057	-0.130	0.102
Hemoglobin	-0.260	0.001	-0.268	0.001
Platelets	-0.289	0.001	-0.308	0.001
Prothrombin time	-0.443	< 0.001	-0.279	0.001
Serum albumin	-0.539	< 0.001	-0.451	< 0.001
Blood urea nitrogen	-0.093	0.152	-0.123	0.716
Serum creatinine	-0.036	0.580	-0.139	0.387
Aspartate aminotransferase	0.443	0.001	0.329	0.001
Alanine aminotransferase	0.225	0.022	0.249	0.001
Total bilirubin	0.538	< 0.001	0.300	0.001
Serum sodium	-0.282	0.001	-0.192	0.015
Hemoglobin A1c	-0.151	0.109	-0.094	0.282
Total cholesterol	-0.244	0.001	-0.231	0.001
BTR	-0.596	0.004	-0.298	0.003
Branched chain amino acid	-0.338	0.001	-0.260	0.374
Tyrosine	0.585	< 0.001	0.455	< 0.001
Ammonia	0.369	< 0.001	0.407	< 0.001
Alpha-fetoprotein	0.074	0.269	-0.051	0.549

The model for end-stage liver disease score, Fibrosis-4 index, aspartate aminotransferase-to-platelet ratio index, and albumin-bilirubin index (ALBI) score were correlated with the autotoxin level in both men and women. The correlation coefficient between ALBI and autotaxin in men was strong. Fib-4: Fibrosis-4; ALBI: Albumin-bilirubin index; MELD: Model for end-stage liver disease; APRI: Aspartate aminotransferase-to-platelet ratio index; BTR: Branched-chain amino acid and tyrosine ratio.