Risk of gastrointestinal cancer in a symptomatic cohort after a complete colonoscopy: Role of faecal immunochemical test

Table 4 Factors associated with upper gastrointestinal cancer detection the first year after baseline colonoscopy, n (%)

	Upper gastrointestinal cancer	Odds ratio (95 %CI)1	Odds ratio (95 %CI)2
Sex
Female (n = 1432)	10 (0.7)	1
Male (n = 1277)	12 (0.9)	1.3 (0.6-3.1)
Age
< 70 yr (n = 1757)	8 (0.5)	1	1
≥ 70 yr (n = 952)	14 (1.5)	3.3 (1.4-7.8)	2.7 (1.1-7.0)
Primary healthcare referral
No (n = 1936)	19 (1.0)	1
Yes (n = 617)	3 (0.5)	0.5 (0.1-1.7)
Rectal bleeding
No (n = 1319)	16 (1.2)	1
Yes (n = 1234)	6 (0.5)	0.4 (0.1-1.0)
Change of bowel habit
No (n = 1282)	12 (0.9)	1
Adequate (n = 1271)	10 (0.8)	0.8 (0.4-1.9)
Anaemia3
No (n = 2077)	13 (0.6)	1	1
Yes (n = 191)	8 (4.2)	6.9 (2.8-17.0)	5.6 (2.2-13.9)
Abdominal pain
No (n = 1319)	12 (1.1)	1
Yes (n = 1234)	5 (0.7)	0.6 (0.2-1.7)
Weight loss
No (n = 1462)	12 (0.8)	1
Yes (n = 391)	5 (1.3)	1.5 (0.5-4.4)
Faecal immunochemical test
< 10 µg/g (n = 1979)	14 (0.7)	1
≥ 10 µg/g (n = 730)	8 (1.1%)	1.5 (0.6-3.7)
Benign anorectal lesion
No (n = 961)	7 (0.7)	1
Yes (n = 756)	6 (0.8)	1.1 (0.4-3.2)
Significant colonic lesion4
No (n = 2216)	16 (0.7)	1
Yes (n = 480)	6 (1.3)	(0.7-4.5)
Advanced adenoma5
No (n = 2968)	16 (0.7)	1
Yes (n = 337)	6 (1.8)	2.5 (1.0-6.4)

¹Differences were analysed with the Chi-square and Cochran–Mantel–Haenszel statistics and expressed as the odds ratio and its 95%CI.

²Variables with statistically significant differences were introduced in a multivariate logistic regression analysis. The association is expressed as odds ratio and its 95 %CI.

³Defined as < 11 g/100 mL in men and < 10 g/100 mL in non-menstruating women.

⁴Advanced adenoma (≥ 10 mm, villous histology, high-grade dysplasia), polyposis (> 10 polyps of any histology), colitis (any aetiology), polyps ≥ 10 mm, complicated diverticular disease, colonic ulcer and/or bleeding angiodysplasia.

⁵Adenoma ≥ 10 mm with villous histology or high-grade dysplasia.