Risk of gastrointestinal cancer in a symptomatic cohort after a complete colonoscopy: Role of faecal immunochemical test

Table 3 Risk of cancer and death according to faecal immunochemical test result

Event	Risk	Overall (n = 2709)	FIT < 10 µg/g (n = 1979)	FIT ≥10 µg/g (n = 730)	RR1 (95%CI)	HR2 (95%CI)
GIC	Cumulative3	2.1% (1.6-2.6)	1.7% (1.1-2.3)	3.2% (1.9-4.4)	1.9 (1.1-3.2)	1.5 (0.8-2.7)
GIC	Density4	5.6 (4.1-7.0)	4.3 (2.9-5.8)	9.7 (5.8-13.7)
GIC	Cumulative death3	1.3% (0.9-1.8)	1.0% (0.5-1.4)	2.3% (1.2-3.4)	2.5 (1.3-4.7)	2.2 (1.1-4.3)
GIC	Death density4	3.5 (2.4-4.6)	2.4 (1.3-3.5)	7.1 (3.7-10.5)
Up GIC5	Cumulative3	1.3% (0.9-1.7)	1.2% (0.7-1.6)	1.6% (0.7-2.6)	1.4 (0.7-2.8)	1.0 (0.5-2.2)
Up GIC5	Density4	3.4 (2.3-4.6)	2.9 (1.7-4.1)	5.1 (2.2-8.0)
Up GIC5	Cumulative death3	0.8% (0.5-1.2)	0.7% (0.3-1.0)	1.2% (0.4-2.0)	1.6 (0.7-3.7)	1.4 (0.6-3.3)
Up GIC5	Death density4	2.1 (1.2-3.0)	1.6 (0.8-2.5)	3.8 (1.3-6.2)
CRC	Cumulative3	0.5% (0.2-0.8)	0.3% (0.1-0.5)	1.1% (0.3-1.9)	3.6 (1.3-10.5)	3.8 (1.2-11.9)
CRC	Density4	1.4 (0.7-2.1)	0.8 (0.2-1.4)	3.4 (1.0-5.7)
CRC	Cumulative death3	0.3% (0.1-0.5)	0.1% (0.0-0.2)	1.0% (0.3-1.7)	9.5 (2.0-46.2)	10.8 (2.1-57.1)
CRC	Death density4	0.9 (0.3-1.4)	0.3 (-0.1-0.6)	2.9 (0.8-5.1)
Cancer	Cumulative3	7.6% (6.6-8.6)	7.3% (6.2-8.5)	8.2% (6.2-10.2)	1.1 (0.8-1.5)	1.1 (0.8-1.5)
Cancer	Density4	20.5 (17.7-23.3)	18.8 (15.8-21.9)	25.9 (19.4-32.5)
Cancer	Cumulative death3	3.6% (2.9-4.3)	3.2% (2.4-4.0)	4.8% (3.2-6.3)	1.5 (1.0-2.3)	1.4 (0.9-2.2)
Cancer	Death density4	9.5 (7.6-11.4)	8.0 (6.0-9.9)	14.7 (9.8-19.6)
Death	Cumulative3	7.3% (6.3-8.2)	7.0% (5.9-8.1)	7.9% (6.0-9.9)	1.1 (0.8-1.5)	1.1 (0.8-1.5)
Death	Density4	19.2 (16.5-21.8)	17.6 (14.7-20.5)	24.3 (18.1-30.6)

¹Differences in cumulative incidence were analysed with the Chi-square and the Cochran–Mantel–Haenszel statistics and expressed as the RR and its 95%CI in the qualitative variables.

²Differences in the risk of cancer and death adjusted by age, sex and presence of significant colonic lesion were analysed with a Cox multivariate regression and expressed as HR and its 95%CI.

³Cumulative risk is expressed as percentage and its 95%CI.

⁴Risk density rate is expressed per 1000 patient-years and its 95%CI.

⁵Defined as a cancer located in the oesophagus, stomach, duodenum or ampulla. CI: Confidence interval; CRC: Colorectal cancer; FIT: Faecal immunochemical test; GIC: Gastrointestinal cancer RR: Risk ratio; Up GIC: Upper gastrointestinal cancer.