Triggers of histologically suspected drug-induced colitis

doi:10.3748/wjg.v25.i8.967

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Feb 28, 2019; 25(8): 967-979
Published online Feb 28, 2019. doi: 10.3748/wjg.v25.i8.967

Table 4 Drug assessment n (%)

Group	Drug-induced colitis, n = 211	Non-inflammatory controls, n = 211	Inflammatory controls, n = 211
Betablocker	97 (46.0)	78 (37.0)	83 (39.3)
ACE inhibitors	70 (33.2)	55 (26.1)	62 (29.4)
Angiotensin II inhibitors	20 (9.5)^b¹	24 (11.4)	6 (2.8)^b³
Non-Dihydropyridines	1 (0.5)^a¹	6 (2.8)	7 (3.3)
Dihydropyridines	34 (16.1)^a¹	27 (12.8)	20 (9.5)
Diuretics	55 (26.1)^b¹	29 (13.7)^b²	33 (15.7)
Benzothiazines	28 (13.3)	33 (15.6)	24 (11.4)
Aldosterone antagonists	13 (6.2)	13 (6.2)	12 (5.7)
Nitrates	7 (3.3)	13 (6.2)	5 (2.4)
Antiarrhythmic drugs	7 (3.3)	2 (0.9)	2 (0.9)
Glycosides	10 (4.7)	2 (0.9)^a²	8 (3.8)
ASS (100 mg to 300 mg)	67 (31.8)^b¹	47 (22.3)^a²	40 (19.0)
Platelet aggregation inhibitors	20 (9.5)^b¹	10 (4.7)	6 (2.8)
NSAIDs	35 (16.6)^b¹	21 (10.0)^a²	8 (3.8)^a³
Metamizole	21 (10.0)	16 (7.6)	21 (10.0)
Potassium	4 (1.9)	3 (1.4)	6 (2.8)
Vitman K antagonists/coumarin derivates	16 (7.6)	9 (4.3)	11 (5.2)
Direct thrombin inhibitors	6 (2.8)	2 (0.9)	4 (1.9)
Glucocorticosteroids	13 (6.2)^b¹	14 (6.6)	41 (19.4)^b³
Opioids	20 (9.5)	22 (10.4)	23 (10.9)
Metformin	8 (3.8)	16 (7.6)	4 (1.9)^b³
Insulin	17 (8.1)	15 (7.1)	17 (8.1)
Statins	56 (26.5)^a¹	42 (19.9)	38 (18.0)
Fibrates	7 (3.3)^a¹	1 (0.5)^a²	1 (0.5)
Levothyroxine	25 (11.8)	39 (18.5)	22 (10.4)^a³
Thyreostatics	3 (1.4)	3 (1.4)	1 (0.5)
Proton pump inhibitors	100 (47.4)	85 (40.3)	81 (38.4)
Penicillin derivates	0 (0.0)	2 (0.9)	2 (0.9)
Macrolides	0 (0.0)	1 (0.5)	1 (0.5)
Gyrase inhibitor	0 (0.0)	0 (0.0)	0 (0.0)
Carbapenems	1 (0.5)	0 (0.0)	0 (0.0)
Imidazoles	3 (1.4)	1 (0.5)	1 (0.5)
Cephalosporins	2 (0.9)	2 (0.9)	2 (0.9)
Antbiotics	4 (1.9)	5 (2.4)	3 (1.4)
SSRIs	14 (6.6)	5 (2.4)^a²	16 (7.6)^a³
Tricyclic antidepressants	7 (3.3)	10 (4.7)	7 (3.3)
Neuroleptics	5 (2.4)	8 (3.8)	6 (2.8)
Sedatives	16 (7.6)	16 (7.6)	16 (7.6)
Others	127 (60.2)^a¹	125 (59.2)	147 (69.7)^a³
Number of drugs^b	4.5 ± 2.8	3.9 ± 3.0^a²	3.9 ± 3.2

¹Drug-induced colitis vs inflammatory controls.

²Drug-induced colitis vs non-inflammatory controls.

³Non-inflammatory controls vs inflammatory controls.

^aP < 0.05.

^bP < 0.01.

Statistical analysis was carried out with χ² test (a) or t-test (b). NSAIDs : Nonsteroidal anti-inflammatory drugs; SSRIs: Selective serotonin reuptake inhibitors; ACE: Angiotensin-converting enzyme.

Citation: Brechmann T, Günther K, Neid M, Schmiegel W, Tannapfel A. Triggers of histologically suspected drug-induced colitis. World J Gastroenterol 2019; 25(8): 967-979
URL: https://www.wjgnet.com/1007-9327/full/v25/i8/967.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i8.967