Triggers of histologically suspected drug-induced colitis

Table 3 Histopathological reassessment n (%)

Parameter (n = 28)	Drug-induced colitis without atherosclerosis	Drug-induced colitis with atherosclerosis	Ischaemiccolitis
Oedema	2 (7.1)	2 (7.1)	4 (14.3)
Haemorrhage	1 (3.6)a2	8 (28.6)a1	6 (21.4)
Lymphocytic infiltration	27 (96.4)	27 (96.4)	27 (96.4)
Granulocytic infiltration	27 (96.4)	26 (92.9)	28 (100.0)
Eosinophilic infiltration	12 (42.9)b2	7 (25.0)	1 (3.6)a3
Erosions	2 (7.1)b2	9 (32.1)a1	10 (35.7)
Ulcerous lesions	4 (14.3)b2	3 (10.7)	16 (57.1)b3
Necrosis	1 (3.6)b2	1 (3.6)	16 (57.1)b3
Fibrin plaques on erosions	2 (7.1)	2 (7.1)	3 (10.7)
Fibrosis	3 (10.7)	3 (10.7)	7 (25.0)

¹Drug-induced colitis without atherosclerosis vs drug-induced colitis with atherosclerosis.

²Drug-induced colitis without atherosclerosis vs ischaemic colitis.

³Drug-induced colitis with atherosclerosis vs ischaemic colitis.

^aP < 0.05.

^bP < 0.01.

Statistical analysis was carried out with χ² test.