Lethal-7-related polymorphisms are associated with susceptibility to and prognosis of gastric cancer

Table 2 The genotype distribution between gastric cancer cases and controls

Gene	SNP	Genotypes	Cases	Controls	P valuea	OR (95% CI)b
let-7a-1	rs13293512	T/T	270 (30.3)	310 (31.5)	0.593	1.00
		T/C	442 (49.6)	494 (50.2)		1.03 (0.83-1.28)
		C/C	180 (20.2)	181 (18.4)		1.13 (0.86-1.48)
let-7a-2	rs562052	G/G	382 (43.0)	439 (44.3)	0.814	1.00
		G/A	413 (46.5)	446 (45.0)		1.06 (0.87-1.29)
		A/A	94 (10.6)	106 (10.7)		0.96 (0.70-1.32)
let-7a-2	rs547008	C/C	529 (59.2)	575 (58.3)	0.875	1.00
		C/T	321 (35.9)	358 (36.3)		0.96 (0.79-1.17)
		T/T	44 (4.9)	53 (5.4)		0.85 (0.56-1.30)
let-7a-2	rs1143770	T/T	255 (28.9)	282 (28.7)	0.262	1.00
		T/C	456 (51.8)	482 (49.0)		1.04 (0.83-1.29)
		C/C	170 (19.3)	219 (22.3)		0.83 (0.64-1.09)
let-7a-2	rs629367	A/A	532 (59.2)	597 (60.3)	0.583	1.00
		A/C	323 (36.0)	355 (35.9)		1.01 (0.83-1.22)
		C/C	43 (4.8)	38 (3.8)		1.21 (0.76-1.92)
let-7i	rs10877887	T/T	370 (42.3)	406 (42.2)	0.777	1.00
		T/C	399 (45.6)	449 (46.7)		0.96 (0.78-1.17)
		C/C	106 (12.1)	107 (11.1)		1.04 (0.76-1.42)
LIN28A	rs3811463	T/T	672 (74.8)	689 (69.5)	0.024	1.00
		T/C	203 (22.6)	265 (26.7)		0.76 (0.61-0.94)
		C/C	23 (2.6)	38 (3.8)		0.59 (0.34-1.01)
	Dominant	T/T	672 (74.8)	689 (69.5)	0.009	1.00
		T/C+C/C	226 (25.2)	303 (30.5)		0.74 (0.60-0.91)
IL23R	rs10889677	A/A	476 (53.2)	545 (55.2)	0.685	1.00
		A/C	356 (39.8)	375 (38.0)		1.10 (0.91-1.34)
		C/C	63 (7.0)	68 (6.9)		1.07 (0.74-1.55)
RAD52	rs7963551	T/T	597 (66.6)	672 (68.0)	0.666	1.00
		T/G	267 (29.8)	287 (29.0)		1.06 (0.87-1.31)
		G/G	32 (3.6)	29 (2.9)		1.18 (0.69-2.01)
KRAS	rs712	G/G	540 (61.0)	589 (60.5)	0.646	1.00
		G/T	296 (33.4)	339 (34.8)		0.94 (0.77-1.15)
		T/T	49 (5.5)	46 (4.7)		1.14 (0.74-1.75)

^aP was computed using the χ² test.

^bORs with 95%CIs were computed using a logistic model after adjusting for age, gender, and Helicobacter pylori status.

SNP: Single nucleotide polymorphism; ORs: Odds ratios; CIs: Confidence intervals.