Targeted and immune therapies for hepatocellular carcinoma: Predictions for 2019 and beyond

doi:10.3748/wjg.v25.i7.789

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 21, 2019; 25(7): 789-807
Published online Feb 21, 2019. doi: 10.3748/wjg.v25.i7.789

Table 5 Results of the CERESTIAL trial[45]

	Cabozantinib (n = 470)	Placebo (n = 237)	HR, P-value
OS (M, 95%CI)	10.2 (9.1-12.0)	8.0 (6.8-9.4)	HR 0.76 (95%CI 0.63-0.92) P = 0.0049
PFS (M, 95%CI)	5.2 (4.0-5.5)	1.9 (1.9-1.9)	HR 0.44 (95%CI 0.36-0.52) P < 0.0001
Objective response (investigator assessed, RECIST 1.1)
CR (%)	0	0
PR (%)	4	0.4
SD (%)	60	33
PD (%)	21	55
NE (%)	15	11
ORR (%, 95CI)	4 (2.3-6.0)	0.4 (0.0-2.3)	P = 0.0086
DCR (%)	64	33.4

OS: Overall survival; PFS: Progression-free survival; TTP: Time to progression; CR: Complete response; PR: Partial response; SD: Stable disease; PD: Progressive disease; NE: Not evaluable; ORR: Objective response rate; DCR: Disease control rate.

Citation: Kudo M. Targeted and immune therapies for hepatocellular carcinoma: Predictions for 2019 and beyond. World J Gastroenterol 2019; 25(7): 789-807
URL: https://www.wjgnet.com/1007-9327/full/v25/i7/789.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i7.789