Claudin-7 gene knockout causes destruction of intestinal structure and animal death in mice

Figure 6 Increased intestinal proliferation in Cldn7 ICKO mice. A-D: Immunohistochemistry staining showed that Cldn7 was strongly expressed in the intestinal epithelial junctions of control mice but significantly weakened in ICKO mice; E-H: In control mice, Ki67 was mainly distributed in parts of the crypt, while Ki67-positive cells occupied the entire intestinal crypt and could be observed throughout the intestinal villi in ICKO mice; I-J: The size of the intestinal crypt in ICKO mice was increased compared with that in control mice (P < 0.001). Cldn7: Claudin-7; ICKO: Inducible conditional knockout.