Contribution of ghrelin to functional gastrointestinal disorders’ pathogenesis

doi:10.3748/wjg.v25.i5.539

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Feb 7, 2019 (publication date) through Nov 23, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 7, 2019; 25(5): 539-551
Published online Feb 7, 2019. doi: 10.3748/wjg.v25.i5.539

Table 1 Comparison of physiological actions of acyl- and des-acyl ghrelin

Parameter	Acyl-ghrelin	Des-acyl ghrelin	Ref.
Appetite¹	Increase	Decrease	[87]
Metabolism¹	Positive energy balance	Negative energy balance	[87]
Adipogenesis	Increase	Increase	[88]
Cardiomyocyte and endothelial cell death	Inhibition	Inhibition	[20]
Papillary muscle contractility	Negative inotropy	Negative inotropy	[89]
Blood pressure	Decrease	Decrease	[90]
Insulin release¹	Decrease	Increase	[91]
Insulin sensitivity¹	Decrease	Increase	[92]
Muscle wasting	Decrease	Decrease	[93]
Gastric emptying¹	Increase	Decrease	[94]
Gastric motility¹	Increase	Decrease	[95]

¹Opposing actions.

Citation: Koutouratsas T, Kalli T, Karamanolis G, Gazouli M. Contribution of ghrelin to functional gastrointestinal disorders’ pathogenesis. World J Gastroenterol 2019; 25(5): 539-551
URL: https://www.wjgnet.com/1007-9327/full/v25/i5/539.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i5.539