Mesenterico-portal vein invasion should be an important factor in TNM staging for pancreatic ductal adenocarcinoma: Proposed modification of the 8th edition of the American Joint Committee on Cancer staging system

Table 3 Differences in survival functions between American Joint Committee on Cancer TNM stages in patients stratified according to whether there was mesenterico-portal vein invasion

	SEER database		West China Hospital database
	MPV- group	MPV+ group	MPV- group	MPV+ group
Stage IA
Median survival	38 (± 3.6)	19 (± 3.4)	32 (± 5.3)	21
1-yr survival rate	84.7% (± 1.7%)	85.7% (± 7.6%)	84.2% (± 4.0%)	100.0%
3-yr survival rate	51.7% (± 2.5%)	26.8% (± 10.9%)	45.4% (± 6.6%)	0.0% (±0.0%)
5-yr survival rate	39.4% (± 2.7%)	26.8% (± 10.9%)	36.0% (± 7.1%)	0.0% (± 0.0%)
Stage IB
Median survival	27 (± 1.3)	22 (± 2.3)	24 (± 1.6)	17 (± 2.3)
1-yr survival rate	78.0% (± 1.3%)	76.6% (± 3.7%)	79.0% (± 2.9%)	72.5% (± 8.3%)
3-yr survival rate	40.1% (± 1.6%)	34.1% (± 4.6%)	27.9% (± 3.8%)	8.55% (± 5.7%)
5-yr survival rate	27.6% (± 1.6%)	23.7% (± 4.4%)	20.9% (± 4.0%)	4.35% (± 4.2%)
Stage IIA
Median survival	20 (± 1.1)	19 (± 6.6)	18 (± 3.7)	15 (± 3.7)
1-yr survival rate	69.8% (± 3.1%)	71.6% (± 7.3%)	59.3% (± 8.5%)	55.6% (± 16.6%)
3-yr survival rate	24.7% (± 3.1%)	32.8% (± 8.5%)	13.7% (± 8.4%)	0.0% (± 0.0%)
5-yr survival rate	13.4% (± 2.7%)	18.4% (± 8.1%)	6.95% (± 6.4%)	0.0% (± 0.0%)
Stage IIB
Median survival	20 (± 0.5)	17 (± 1.1)	18 (± 1.0)	15 (± 4.8)
1-yr survival rate	68.7% (± 0.9%)	63.6% (± 2.8%)	66.7% (± 3.5%)	63.3% (± 7.1%)
3-yr survival rate	26.3% (± 0.9%)	15.3% (± 2.3%)	14.1% (± 3.1%)	7.95% (± 4.3%)
5-yr survival rate	15.9% (± 0.8%)	9.25% (± 2.1%)	5.65% (± 2.9%)	0.0% (± 0.0%)
Stage III
Median survival	16 (± 0.4)	13 (± 1.2)	15 (± 2.8)	15 (± 4.8)
1-yr survival rate	60.0% (± 1.1%)	53.1% (± 3.9%)	53.3% (± 8.4%)	53.9% (± 14.1%)
3-yr survival rate	17.6% (± 1.0%)	8.65% (± 2.6%)	10.4% (± 6.1%)	0.0% (± 0.0%)
5-yr survival rate	8.15% (± 0.8%)	6.55% (± 2.4%)	0.0% (± 0.0%)	0.0% (± 0.0%)
IA vs IB
Survival function	P = 0.000a	P = 0.917	P = 0.044a	P = 0.382
1-yr survival rate	P = 0.002a	P = 0.282	P = 0.293
3-yr survival rate	P = 0.000a	P = 0.537	P = 0.022a	P = 0.136
5-yr survival rate	P = 0.000a	P = 0.792	P = 0.064	P = 0.306
IB vs IIA
Survival function	P = 0.000a	P = 0.486	P = 0.003a	P = 0.264
1-yr survival rate	P = 0.015a	P = 0.541	P = 0.028a	P = 0.363
3-yr survival rate	P = 0.000a	P = 0.893	P = 0.124	P = 0.136
5-yr survival rate	P = 0.000a	P = 0.565	P = 0.064	P = 0.306
IIA vs IIB
Survival function	P = 0.622	P = 0.136	P = 0.523	P = 0.500
1-yr survival rate	P = 0.733	P = 0.306	P = 0.421	P = 0.670
3-yr survival rate	P = 0.620	P = 0.047a	P = 0.964	P = 0.066
5-yr survival rate	P =0.375	P = 0.272	P = 0.853
IIB vs III
survival function	P = 0.000a	P = 0.053	P = 0.033a	P = 0.418
1-yr survival rate	P = 0.000a	P = 0.029a	P = 0.141	P = 0.552
3-yr survival rate	P = 0.000a	P = 0.054	P = 0.589	P = 0.066
5-yr survival rate	P = 0.000a	P =0.397	P = 0.053

Values in parentheses are the standard error of median survival or standard error of survival rate.

^aP < 0.05. SEER: Surveillance, epidemiology, and end results; MPV: Mesenterico-portal vein.