Mesenterico-portal vein invasion should be an important factor in TNM staging for pancreatic ductal adenocarcinoma: Proposed modification of the 8th edition of the American Joint Committee on Cancer staging system

doi:10.3748/wjg.v25.i46.6752

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World Journal of Gastroenterology

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Retrospective Cohort Study

World J Gastroenterol. Dec 14, 2019; 25(46): 6752-6766
Published online Dec 14, 2019. doi: 10.3748/wjg.v25.i46.6752

Table 2 Univariate and multivariate analyses of the survival of patients with pancreatic ductal adenocarcinoma

Univariate	SEER database			West China Hospital database
Univariate	Hazard ratio (95%CI)		P value	Hazard ratio (95%CI)		P value
Sex
Male	1.000	Reference		1.000	Reference
Female	0.931	(0.879, 0.987)	0.017^a	0.861	(0.709, 1.046)	0.132
Tumor diameter			0.000^a			0.000^a
≤ 2 cm (T1)	1.000	Reference		1.000	Reference
> 2 cm but ≤ 4 cm (T2)	1.375	(1.267, 1.492)	0.000^a	1.466	(1.145, 1.878)	0.002^a
> 4 cm (T3)	1.796	(1.629, 1.982)	0.000^a	2.466	(1.789, 3.397)	0.000^a
Positive lymph nodes			0.000^a			0.000^a
0 (N0)	1.000	Reference		1.000	Reference
1-3 (N1)	1.527	(1.419, 1.644)	0.000^a	1.676	(1.378, 2.039)	0.000^a
> 4 (N2)	1.940	(1.791, 2.100)	0.000^a	2.466	(1.774, 3.429)	0.000^a
MPV invasion	1.170	(1.059, 1.293)	0.002^a	1.708	(1.352, 2.159)	0.000^a
Multivariate	SEER database			West China Hospital database
Multivariate	Hazard ratio (95%CI)		P	Hazard ratio (95%CI)		P
Sex
Male	1.000	Reference
Female	0.937	(0.887, 0.989)	0.018^a
Tumor diameter			0.000^a			0.000^a
T1	1.000	Reference		1.000	Reference
T2	1.299	(1.203, 1.404)	0.000^a	1.361	(1.060, 1.746)	0.015^a
T3	1.611	(1.468, 1.768)	0.000^a	2.079	(1.500, 2.880)	0.000^a
Positive lymph nodes			0.000^a			0.000^a
N0	1.000	Reference		1.000	Reference
N1	1.454	(1.358, 1.557)	0.000^a	1.573	(1.290, 1.916)	0.000^a
N2	1.842	(1.710, 1.984)	0.000^a	2.127	(1.523, 2.971)	0.000^a
MPV invasion	1.178	(1.071, 1.290)	0.000^a	1.423	(1.120, 1.807)	0.004^a

^aP < 0.05. SEER: Surveillance, epidemiology, and end results; MPV: Mesenterico-portal vein.

Citation: Chen HY, Wang X, Zhang H, Liu XB, Tan CL. Mesenterico-portal vein invasion should be an important factor in TNM staging for pancreatic ductal adenocarcinoma: Proposed modification of the 8^th edition of the American Joint Committee on Cancer staging system. World J Gastroenterol 2019; 25(46): 6752-6766
URL: https://www.wjgnet.com/1007-9327/full/v25/i46/6752.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i46.6752