Mesenterico-portal vein invasion should be an important factor in TNM staging for pancreatic ductal adenocarcinoma: Proposed modification of the 8th edition of the American Joint Committee on Cancer staging system

doi:10.3748/wjg.v25.i46.6752

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Dec 14, 2019 (publication date) through Apr 6, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Gastroenterol. Dec 14, 2019; 25(46): 6752-6766
Published online Dec 14, 2019. doi: 10.3748/wjg.v25.i46.6752

Table 1 Characteristics of patients enrolled in this study, n (%)

Characteristic	SEER database			West China Hospital database
Characteristic	MPV- group	MPV+ group	P value	MPV- group	MPV+ group	P value
Sample size, n	6825	714		579	110
Sex			0.041^a			0.353
Male	3458 (50.7)	333 (46.6)		368 (63.6)	75 (68.2)
Female	3367 (49.3)	381 (53.4)		211 (36.4)	35 (31.8)
Age at diagnosis (± SEM)	66.4 (± 0.13)	65.4 (± 0.38)	0.019^a	58.4 (± 0.41)	58.35 (± 0.88)	0.998
Tumor diameter			0.000^a			0.003^a
≤ 2 cm	1232 (18.1)	62 (8.7)		130 (22.5)	12 (10.9)
> 2 cm but ≤ 4 cm	4377 (64.1)	482 (67.5)		373 (64.4)	73 (66.4)
> 4 cm	1216 (17.8)	170 (23.8)		76 (13.1)	25 (22.7)
Positive lymph nodes			0.161			0.001^a
0	1900 (27.8)	214 (30.0)		345 (59.6)	46 (41.8)
1-3	2893 (42.4)	311 (43.6)		195 (33.7)	48 (43.6)
≥ 4	2032 (29.8)	189 (26.5)		39 (6.7)	16 (14.5)
AJCC 8^th stage			0.000^a			0.000^a
IA	500 (7.3)	22 (3.1)		89 (15.4)	4 (3.6)
IB	1162 (17.0)	19 (20.9)		219 (37.8)	31 (28.2)
IIA	238 (3.5)	43 (6.0)		37 (6.4)	11 (10.0)
IIB	2893 (42.4)	311 (43.6)		195 (33.7)	45 (43.6)
III	2032 (29.8)	189 (26.5)		39 (6.7)	16 (14.5)
Perineural invasion			N/A			0.016^a
Absent	N/A	N/A		165 (28.3)	19 (17.3)
Present	N/A	N/A		415 (71.7)	91 (82.7)
Intravascular tumor emboli			N/A			0.971
Absent	N/A	N/A		494 (85.3)	94 (85.5)
Present	N/A	N/A		85 (14.7)	16 (14.5)
Grade¹			0.605			0.984
Well differentiated	632 (9.3)	59 (8.3)		5 (0.9)	1 (1.0)
Moderately differentiated	3397 (49.8)	314 (44.0)		215 (38.1)	37 (37.4)
Poorly/undifferentiated	2489 (36.5)	251 (35.1)		344 (61.0)	61 (61.6)
Unknown	307 (4.5)	90 (12.6)		0 (0.0)	0 (0.0)
Margin status²			N/A			0.000^a
R0	N/A	N/A		427 (73.7)	61 (55.5)
R1	N/A	N/A		152 (26.3)	49 (44.5)
R2	N/A	N/A		0 (0.0)	0 (0.0)

¹Row "Unknown" was excluded from the crosstab chi-square analysis.

²The last row was excluded from the crosstab chi-square analysis since the expected frequencies were equal to 0.

^aP < 0.05. SEER: Surveillance, epidemiology, and end results; MPV: Mesenterico-portal vein; SEM: Standard error of the mean; N/A: Not available.

Citation: Chen HY, Wang X, Zhang H, Liu XB, Tan CL. Mesenterico-portal vein invasion should be an important factor in TNM staging for pancreatic ductal adenocarcinoma: Proposed modification of the 8^th edition of the American Joint Committee on Cancer staging system. World J Gastroenterol 2019; 25(46): 6752-6766
URL: https://www.wjgnet.com/1007-9327/full/v25/i46/6752.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i46.6752