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©The Author(s) 2019.
World J Gastroenterol. Dec 7, 2019; 25(45): 6634-6652
Published online Dec 7, 2019. doi: 10.3748/wjg.v25.i45.6634
Published online Dec 7, 2019. doi: 10.3748/wjg.v25.i45.6634
Figure 8 M2 cells reduced iNOS expression in M1 inflammatory macrophages.
LV-rop16I/III-induced M2-like macrophages restricted the production of iNOS in M1 cells. A and B: The iNOS level was downregulated in mixed M1 and M2 cells relative to that in M1 cells. A, C-E: Arg-1 and PD-L2 expression was higher in M2 cells than in Lv-Mφ cells. The above proteins were detected by Western blotting, and the data were analyzed by grey values. aP < 0.05 vs lipopolysaccharide (LPS) + Mφ; bP < 0.01 vs Mφ; cP < 0.001 vs Lv-Mφ, dP < 0.001 vs LPS + Mφ. iNOS: Inducible nitric oxide synthase; PD-L2: Programmed death ligand-2; Arg-1: Arginase-1; Mφ: Macrophages; LPS: Lipopolysaccharide; LV-Mφ: Lentivirus transfer into macrophages; LV-rop16I/III-Mφ: Lentivirus-rop16I/III transfer into macrophages.
- Citation: Xu YW, Xing RX, Zhang WH, Li L, Wu Y, Hu J, Wang C, Luo QL, Shen JL, Chen X. Toxoplasma ROP16I/III ameliorated inflammatory bowel diseases via inducing M2 phenotype of macrophages. World J Gastroenterol 2019; 25(45): 6634-6652
- URL: https://www.wjgnet.com/1007-9327/full/v25/i45/6634.htm
- DOI: https://dx.doi.org/10.3748/wjg.v25.i45.6634