MicroRNA-760 acts as a tumor suppressor in gastric cancer development via inhibiting G-protein-coupled receptor kinase interacting protein-1 transcription

Figure 3 MicroRNA-760 suppresses G-protein-coupled receptor kinase interacting protein-1 expression in gastric cancer. A: The binding site between microRNA-760 (miR-760) and G-protein-coupled receptor kinase interacting protein-1 (GIT1); B: Luciferase reporter assay; C: A negative correlation between miR-760 and GIT1 in gastric cancer tissues; D and E: GIT1 expression in MKN-45 and AGS cells transfected with miR-760 mimic or inhibitor. ^bP < 0.01. GC: Gastric cancer; Mut: Mutant; Wt: Wild-type; 3'-UTR: 3'-untranslated region; NC: Negative control; MiR-760: MicroRNA-760; GIT1: G-protein-coupled receptor kinase interacting protein-1.