Real life efficacy and safety of direct-acting antiviral therapy for treatment of patients infected with hepatitis C virus genotypes 1, 2 and 3 in northwest China

Table 4 Baseline data for patients with and without sustained virological responses (by modified intention-to-treat analysis)

	Non-SVR12 (n = 11)	SVR12 (n = 315)	P value
Age (yr)	54.1 ± 13.5	51.8 ±11.9	0.098
Gender (males, %)	4 (36.4)	162 (51.4)3	0.080
TBil (µmol/L)	20.16 ± 10.13	19.58 ± 10.69	0.184
ALT (U/L)	62.45 ± 53.85	52.28 ± 46.14	0.034
AST (U/L)	42.73 ± 30.30	47.29 ± 39.74	0.516
Albumin (g/L)	37.7 ± 10.0	39.6 ± 8.6	0.214
TCHO (mmol/L)	3.93 ± 0.59	3.85 ± 0.60	0.879
Hemoglobin (mg/dL)	119.1 ± 15.0	119.5 ± 23.8	0.497
Platelets (109/L)	165.6 ± 68.4	144.9 ± 76.0	0.167
AFP (ng/mL)	5.03 ± 4.49	4.77 ± 6.15	0.407
Log10 HCV RNA (IU/mL)	6.5 ± 0.6	6.5 ± 1.0	0.450
Cirrhosis, n (%)	5 (45.5)	138 (43.8)	0.621
Treatment experienced, n (%)	1 (9.1)	49 (15.6)	0.052

TBil: Total bilirubin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; TCHO: Total cholesterol; AFP: Alpha fetoprotein; HCV: Hepatitis C virus; SVR12: Sustained virological response at post-treatment week 12.