Serum amyloid A levels in patients with liver diseases

Table 2 Single factor analysis of serum levels of serum amyloid A in patients with chronic hepatitis B

Factor	SAA < 6.4 mg/L	SAA ≥ 6.4 mg/L	χ2/t value1	P1 value	OR (95%CI)
	Positive cases/total cases (%)	Positive cases/total cases (%)
Female	39/182 (21.4%)	6/23 (26.1%)	0.259	0.611	1.294 (0.478-3.503)
Age (yr)	47.87 ± 13.17	49.26 ± 14.476	-0.471	0.638	-
ALT ≥ 40 U/L	53/178 (29.8%)	7/22 (31.8%)	0.039	0.844	1.101 (0.424-2.854)
AST ≥ 35 U/L	68/178 (38.2%)	7/22 (31.8%)	0.340	0.560	0.755 (0.293-1.946)
γ-GT ≥ 45 U/L	60/178 (33.7%)	9/22 (40.9%)	0.449	0.503	1.362 (0.551-3.365)
ALP ≥ 135 U/L	12/179 (6.70%)	5/22 (22.7%)	4.592	0.032	4.093 (1.288-13.011)
Elevated ALP or γ-GT level	63/178 (35.4%)	10/22 (45.5%)	0.855	0.355	1.521 (0.622-3.718)
AFP ≥ 20 ng/mL	16/173 (9.2%)	3/22 (13.6%)	0.074	0.786	1.549 (0.413-5.810)
A/G ≤ 1.2	32/177 (18.1%)	7/22 (31.8%)	1.553	0.213	2.115 (0.797-5.608)
Active CHB	44/182 (24.2%)	15/23 (65.2%)	16.78	< 0.001	5.881 (2.337-14.797)
Child-Pugh grade B or C	19/182 (10.4%)	6/23 (26.1%)	3.322	0.068	1.212 (0.946-1.552)
Complicated by UGIB	5/152 (3.29%)	1/20 (5.00%)	0.000	1.000	1.547 (0.172-13.959)
Complicated by HE	4/152 (2.63%)	1/20 (5.00%)	0.000	1.000	1.947 (0.207-18.343)
Complicated by ascites	19/152 (12.5%)	6/20 (30.0%)	3.062	0.080	3.000 (1.029-8.749)
Complicated by UGIB or HE or ascites	23/152 (15.1%)	6/20 (30.0%)	1.828	0.176	2.404 (0.838-6.898)
Complicated by HCC	28/182 (15.4%)	3/23 (13.0%)	0.000	1.000	0.825 (0.230-2.963)
CRP ≥ 3 mg/L	5/35 (14.3%)	7/7 (100%)	17.01	< 0.001	6.993 (3.106-15.873)
HBsAg	160/168 (95.2%)	20/22 (90.9%)	0.121	0.728	0.500 (0.099-2.521)
HBV DNA ≥ 2000 IU/mL	43/177 (24.3%)	4/21 (19.0%)	0.285	0.593	0.733 (0.234-2.297)
Received antiviral therapy	87/162 (53.7%)	13/22 (59.1%)	0.227	0.634	1.245 (0.504-3.076)

¹Continuous normal distribution data were analyzed by the t-test to determine the difference between two groups. Enumeration data were analyzed by the chi-square test to analyze the difference between groups. ALT: Alanine transaminase; AST: Aspartate transaminase; γ-GT: γ-glutamyltransferase; ALP: Alkaline phosphatase; AFP: Alpha-fetoprotein; A/G: Albumin/globulin ratio; HCC: Hepatocellular carcinoma; CRP: C-reactive protein; UGIB: Upper gastrointestinal bleeding; HE: Hepatic encephalopathy; SAA: Serum amyloid A; CHB: Chronic hepatitis B.