Altered profiles of fecal metabolites correlate with visceral hypersensitivity and may contribute to symptom severity of diarrhea-predominant irritable bowel syndrome

Table 4 Multiple linear regression model for irritable bowel syndrome symptom severity scale score

Metabolites	Unstandardized coefficients		Standard-ized coefficie-nts β	t	P value	Collinearity statistics
	b	SE				Tolerance	VIF
Hexanoate1	116.194	29.961	0.420	3.878	0.001	0.903	1.107
Fumarate1	-1733.224	490.683	-0.383	-3.532	0.002	0.902	1.108
Pyruvate1	140.381	28.619	0.528	4.905	< 0.001	0.915	1.092
Asp	-15.303	7.943	-0.221	-1.927	0.066	0.807	1.240
Tyr1	60.960	15.019	0.763	4.059	< 0.001	0.300	3.333
Val1	-82.922	26.139	-0.626	-3.172	0.004	0.272	3.671

¹Metabolite which was correlated with irritable bowel syndrome symptom severity scale score (P< 0.01); SE: Standard error; VIF: Variance inflation factor.