Altered profiles of fecal metabolites correlate with visceral hypersensitivity and may contribute to symptom severity of diarrhea-predominant irritable bowel syndrome

Table 3 Correlation of bristol stool form scale scores with the levels of His, Ala, Tyr, Phe, or Trp

Metabolites	IBS-D		Controls		All subjects
	r	P value	r	P value	r	P value
His	0.057	0.764	0.423	0.117	-0.279	0.064
Ala	-0.026	0.892	0.338	0.218	-0.252	0.095
Tyr	-0.208	0.271	0.423	0.117	-0.3471	0.019
Phe	0.002	0.994	0.465	0.081	-0.250	0.098
Trp	-0.114	0.548	0.423	0.117	-0.268	0.075

¹There was association between parameters (P < 0.05). IBS-D: Irritable bowel syndrome with predominant diarrhea.