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©The Author(s) 2019.
World J Gastroenterol. Nov 21, 2019; 25(43): 6416-6429
Published online Nov 21, 2019. doi: 10.3748/wjg.v25.i43.6416
Published online Nov 21, 2019. doi: 10.3748/wjg.v25.i43.6416
Table 2 Levels of partial fecal metabolites in irritable bowel syndrome with predominant diarrhea patients and controls
Metabolites | Prevalence of detection | IBS-D patients (μmol/g) | Controls (μmol/g) | P value |
His | 93.3% | 0.0642 (0.0388, 0.1484)a | 0.2636 (0.0780, 0.3966) | 0.012 |
Ala | 100.0% | 0.5095 (0.2826, 0.9183)a | 1.0118 (0.6135, 1.4335) | 0.041 |
Tyr | 88.9% | 0.1024 (0.0173, 0.4527)a | 0.5665 (0.2436, 1.3447) | 0.018 |
Phe | 97.8% | 0.1511 (0.0775, 0.3248)a | 0.3967 (0.1388, 0.7550) | 0.028 |
Trp | 77.8% | 0.0323 (0.0001, 0.0826)a | 0.0834 (0.0170, 0.1759) | 0.046 |
Val | 100.0% | 0.2710 (0.1208, 0.5729) | 0.3661 (0.2960, 1.0122) | 0.079 |
Asp | 97.8% | 0.3086 (0.1797, 0.6904) | 0.4875 (0.1939, 0.6591) | 0.647 |
Fumarate | 100.0% | 0.0042 (0.0026, 0.0108) | 0.0019 (0.0014, 0.0078) | 0.051 |
Pyruvate | 100.0% | 0.0067 (0.0023, 0.0719) | 0.0071 (0.0022, 0.0882) | 0.718 |
Butyrate | 100.0% | 4.3819 (2.4060, 9.0920) | 5.8539 (1.5193, 12.8616) | 0.613 |
Isobutyrate | 100.0% | 6.8609 (0.5068, 8.9326) | 2.1277 (0.5470, 10.4635) | 0.962 |
Valerate | 100.0% | 0.2024 (0.0331, 0.8245) | 0.2059 (0.0497, 1.2489) | 0.485 |
Isovalerate | 100.0% | 0.1218 (0.0495, 0.3227) | 0.1661 (0.0416, 0.2581) | 0.866 |
Hexanoate | 100.0% | 0.0254 (0.0189, 0.0513) | 0.0383 (0.0153, 0.0539) | 0.613 |
Isohexanoate | 100.0% | 0.0127 (0.0060, 0.0246)a | 0.0070 (0.0023, 0.0106) | 0.028 |
Amino acids | NA | 7.2873 (3.4177, 10.7709) | 8.0603 (6.1393, 12.3225) | 0.336 |
SCFA | NA | 25.8082 (18.5826, 38.5067) | 26.8452 (5.7182, 70.6763) | 0.904 |
Organic acids | NA | 26.6708 (20.0617, 38.5860) | 26.9449 (5.8047, 71.4057) | 0.866 |
- Citation: Zhang WX, Zhang Y, Qin G, Li KM, Wei W, Li SY, Yao SK. Altered profiles of fecal metabolites correlate with visceral hypersensitivity and may contribute to symptom severity of diarrhea-predominant irritable bowel syndrome. World J Gastroenterol 2019; 25(43): 6416-6429
- URL: https://www.wjgnet.com/1007-9327/full/v25/i43/6416.htm
- DOI: https://dx.doi.org/10.3748/wjg.v25.i43.6416