Changes of gastric ulcer bleeding in the metropolitan area of Japan

Figure 2 Rate of antacid administration prior to treatment (histamine type 2 receptor blockers and proton pump inhibitors). A: Administration of proton pump inhibitors (PPIs) increased significantly over time (P = 0.04), but that of histamine type 2 receptor blockers did not (P = 0.48). B: In patients taking non-steroidal anti-inflammatory drugs, antiplatelets, and/or anticoagulants, there was no significant trend in H₂ blocker and PPI administration over time (P = 0.63 and P = 0.12).