Knockdown of lncRNAXLOC_001659 inhibits proliferation and invasion of esophageal squamous cell carcinoma cells

Figure 1 Knockdown of lncRNAXLOC_001659 inhibits the growth and invasion of esophageal squamous cell carcinoma cells. A: LncRNA XLOC_001659 expression in normal esophageal epithelial cells (HET-1A) and esophageal squamous cell carcinoma cells (EC9706 and EC-1). The results are presented as the mean ± standard deviation from three independent experiments. ^aP < 0.05 and ^bP < 0.01, Student’s t-test; B: LncRNAXLOC_001659 expression in EC9706 and EC-1 cells transfected with si-Lnc was significantly lower than that in the cells of the NC group. ^bP < 0.01; C: CCK-8 assay showed that the proliferation ability of EC9706 and EC-1 cells in the si-Lnc group was significantly lower than in the corresponding NC and blank control groups; D: Colony formation assay showed that EC9706 and EC-1 cells transfected with si-Lnc had a significantly lower proliferation ability than the NC group. ^bP < 0.01; E: EC9706 and EC-1 cells in the si-Lnc groups had significantly fewer invasive cells detected in the Transwell invasion assay than the corresponding NC groups. ^bP < 0.01.