Risk of inflammatory bowel disease in patients with chronic obstructive pulmonary disease: A nationwide, population-based study

Table 3 Incidence and risk of inflammatory bowel disease in patients with chronic obstructive pulmonary disease according to disease severity

		Event	DURATION (Person-years)	Incidence rateof IBD	Model 11 HR (95%CI)	Model 22 HR (95%CI)	P value
		IBD
COPD Severity	Non	1846	25697723.08	7.18	1 (Ref.)	1 (Ref.)	< 0.001
	Mild	461	4719752.21	9.77	1.36 (1.23-1.50)	1.35 (1.22-1.49)
	Sev-ere	52	419531.18	12.39	1.717 (1.29-2.24)	1.70 (1.27-2.21)
		UC
COPD Severity	Non	1540	25697723.08	5.99	1 (Ref.)	1 (Ref.)	< 0.001
	Mild	371	4719752.21	7.86	1.31 (1.17-1.47)	1.31 (1.17-1.47)
	Sev-ere	35	419531.18	8.34	1.39 (0.97-1.91)	1.38 (0.96-1.89)
		CD
COPD Severity	Non	306	25697723.08	1.19	1 (Ref.)	1 (Ref.)	< 0.001
	Mild	90	4719752.21	1.91	1.60 (1.26-2.02)	1.548 (1.22-1.95)
	Sev-ere	17	419531.18	4.05	3.38 (2.00-5.33)	3.29 (1.94-5.20)

¹Model 1: adjustment for age and sex;

²Model 2: adjustment for model 1+ place of resident, income, diabetes mellitus, hypertension, dyslipidemia. CD: Crohn’s disease; CI: Confidence interval; COPD: Chronic obstructive pulmonary disease; HR: Hazard ratio; IBD: Inflammatory bowel disease; UC: Ulcerative colitis.