MicroRNA signature in patients with hepatocellular carcinoma associated with type 2 diabetes

Table 8 Diagnostic ability for studied microRNAs to screening hepatocellular carcinoma among diabetics and controls

Serum miRNA	AUC value	Sensitivity	Specificity	PPV	NPV	Accuracy
miR-16
HCC against ctrl	0.897	81.0%	92.0%	90.6%	86.2%	90.1%
HCC against LC-T2D	0.864	84.9%	87.5%	83.0%	97.5%	88.7%
miR-122-5p
HCC against ctrl	0.793	79.8%	76.2%	80.0%	81.0%	81.3%
HCC against LC-T2D	0.802	83.2%	86.1%	69.0%	86.0%	83.2%
miR-198
HCC against ctrl	0.798	81.4%	79.4%	77.1%	82.0%	80.3%
HCC against LC-T2D	0.791	80.2%	85.2%	54.0%	86.0%	80.0%
miR-199a-3p
HCC against ctrl	0.901	99.7%	97.7%	86.7%	100%	96.7%
HCC against LC-T2D	0.843	82.6%	85.3%	75.7%	96.6%	83.6%
miR-221
HCC against ctrl	0.782	79.4%	80.4%	87.1%	93.7%	81.2%
HCC against LC-T2D	0.780	78.6%	81.8%	34.9%	91.0%	60.8%
miR-23b-3p
HCC against ctrl	0.792	81.0%	83.2%	76.1%	82.0%	79.8%
HCC against LC-T2D	0.689	72.5%	69.5%	30.6%	73.4%	72.7%
miR-34a
HCC against ctrl	0.761	96.4%	59.5%	83.4%	90.7%	75.4%
HCC against LC-T2D	0.789	96.4%	69.3%	46.0%	93.2%	78.2%

AUC: Area under the curve; ctrl: Control; HCC: Hepatocellular carcinoma; LC-T2D: Liver cirrhosis in type 2 diabetic; miRNA: MicroRNA; NPV: Negative predictive value; PPV: Positive predictive value.