MicroRNA signature in patients with hepatocellular carcinoma associated with type 2 diabetes

doi:10.3748/wjg.v25.i42.6322

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 14, 2019; 25(42): 6322-6341
Published online Nov 14, 2019. doi: 10.3748/wjg.v25.i42.6322

Table 10 Levels of serum microRNA s in correlation to type 2 diabetes mellitus-related parameters

		hsa-miR-16	hsa-miR122-5p	hsa-miR-198	hsa-miR199a-3p	hsa-miR221	hsa-miR23b-3p	hsa-miR34a
HbA1c, %	r²	0.312	0.027	0.017	0.087	0.156	0.384	0.498
HbA1c, %	P	< 0.001^a	0.758	0.369	0.08	0.003^a	< 0.001^a	< 0.001^a
GLU in mg/dL	r²	0.269	0.353	0.099	0.17	0.109	0.409	0.087
GLU in mg/dL	P	0.001^a	< 0.001^a	0.026	0.003^a	0.016	< 0.001^a	0.08
Insulin in mU/L	r²	0.091	0.412	0.041	0.47	0.031	0.497	0.063
Insulin in mU/L	P	0.003^a	< 0.001^a	0.209	< 0.001^a	0.003^a	< 0.00^a	0.003^a
HOMA-IR	r²	0.096	0.419	0.013	0.098	0.49	0.492	0.027
HOMA-IR	P	0.03	< 0.001^a	0.396	0.001^a	< 0.001^a	< 0.001^a	0.001^a
ISI	r²	0.095	0.421	0.102	0.019	0.499	0.545	0.0693
ISI	P	0.0074^a	< 0.001^a	0.023	0.004^a	< 0.001^a	< 0.001^a	0.005^a
HIRI	r²	0.498	0.429	0.024	0.1807	0.427	0.672	0.049
HIRI	P	< 0.001^a	< 0.001^a	0.005	< 0.001^a	< 0.001^a	< 0.001^a	0.009^a

Relationship was evaluated through a linear regression analysis adjusted by body mass index, sex, age, high-density lipoproteins, and triglycerides, using SPSS software.

^aP < 0.05. GLU: Glucose; HbA1c: Glycosylated hemoglobin; HIRI: Hepatic insulin resistance index; HOMA-IR: Homeostasis model assessment-insulin resistance; ISI: Insulin sensitivity index; T2DM: Type 2 diabetes mellitus.

Citation: Elemeery MN, Mohamed MA, Madkour MA, Shamseya MM, Issa NM, Badr AN, Ghareeb DA, Pan CH. MicroRNA signature in patients with hepatocellular carcinoma associated with type 2 diabetes. World J Gastroenterol 2019; 25(42): 6322-6341
URL: https://www.wjgnet.com/1007-9327/full/v25/i42/6322.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i42.6322