Increased circulating circular RNA_103516 is a novel biomarker for inflammatory bowel disease in adult patients

Figure 2 Circular RNA_103516 relative expression in patients with Crohn’s disease, patients with ulcerative colitis, healthy controls, and patient controls. Circular RNA (circRNA)_103516 was increased in Crohn’s disease (CD) and ulcerative colitis (UC) patients compared with healthy controls (HC) and patient controls (PC). A significant difference in circRNA_103516 was detected between CD and UC groups. Comparing the relative circRNA levels between two groups was performed by the Mann Whitney U-test. ^aP < 0.05 vs HC and ^bP < 0.001 vs HC; ^cP < 0.05 vs PC; ^dP < 0.001 vs PC; ^eP < 0.05 vs UC. P < 0.05 was considered statistically significant. CD: Crohn’s disease, UC: Ulcerative colitis, HC: Healthy controls, PC: Patient controls; CircRNA: Circular RNA.