Increased circulating circular RNA_103516 is a novel biomarker for inflammatory bowel disease in adult patients

Table 5 Univariate logistic regression analysis showing the disease phenotypes of Crohn’s disease in correlation to circular RNA_103516 status as dependent variable

Clinical variable	n	CircRNA_103765 + (%)	Crude			Adjusted
			OR	95%CI	P value	OR	95%CI	P value
Gender
Male	48	66.7
Female	42	64.3	1.11	0.465-2.655	0.813	NS
Age
< 40 yr	47	57.4
≥ 40 yr	43	74.4	2.155	0.879-5.281	0.093	NS
Smoking status
Never	60	68.3
Past or current use	30	60.0	1.439	0.579-3.577	0.434	NS
Disease location of CD
L1	37	64.7
L2	20	64.7	0.524	0.094-2.930	0.462	NS
L3	33	63.3	0.522	0.082-3.364	0.496
Disease activity of CD
Mild	19	47.4
Moderate	40	82.5	5.238	1.554-17.653	0.008	4.886	1.384-17.251	0.014
Severe	15	80.0	4.444	0.941-21.001	0.025	4.416	0.084-22.054	0.043
Disease behavior of CD
B1	39	48.7
B2	33	78.8	3.910	1.376-11.110	0.011	3.641	1.245-10.650	0.018
B3	18	77.8	3.684	1.028-13.202	0.045	4.375	1.147-16.690	0.031
Medications
5-ASA	80	73.8	1.309	0.340-5.035	0.696	NS
Corticosteroids	50	74.0	2.329	0.959-5.655	0.062	NS
Immunosuppressants	28	67.9	1.161	0.450-2.998	0.758	NS
Anti-TNF-α	13	76.9	1.905	0.483-7.505	0.357	NS
Surgery	4	75.0	1.607	0.160-16.130	0.687	NS

The data are shown with crude and adjusted odds ratios and 95% confidence intervals accordingly. L1: Terminal ileum; L2: Colon; L3: Ileocolon; B1: Non-stricture and non-penetrating; B2: Stricturing; B3: Penetrating; CD: Crohn’s disease; 5-ASA: 5-aminosalicylic acid; TNF-α: Tumor necrosis factor α; NS: No significance; OR: Odds ratio; CI: Confidence interval; CircRNA: Circular RNA.