Blood parameters score predicts long-term outcomes in stage II-III gastric cancer patients

Table 2 Univariate and multivariate analyses for overall survival in the developing and validation cohorts

Variables	Developing cohort (n = 567)				Validation cohort (n = 283)
	Univariate analysis		Multivariate analysis		Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value
Age (yr)		0.005		0.144		0.001		0.008
< 60	Reference		Reference		Reference		Reference
≥ 60	1.432 (1.115-1.838)		1.215 (0.936-1.579)		1.758 (1.262-2.449)		1.617 (1.132-2.311)
Gender		0.502				0.900
Male	Reference		Not included		Reference		Not included
Female	1.098 (0.835-1.444)				0.974 (0.644-1.473)
Body mass index		0.058				0.025		0.241
< 18.5	Reference		Not included		Reference		Reference
18.5-23.9	0.734 (0.509-1.060)				0.551 (0.325-0.934)		0.720 (0.415-1.247)
> 23.9	0.597 (0.390-0.913)				0.413 (0.217-0.788)		0.645 (0.328-1.270)
BPM score		< 0.001		< 0.001		< 0.001		0.004
Low	Reference		Reference		Reference		Reference
High	2.429 (1.893-3.117)		1.993 (1.534-2.589)		2.363 (1.677-3.330)		1.717 (1.913-2.470)
Tumor stage		< 0.001		< 0.001		< 0.001		< 0.001
IIa	Reference		Reference		Reference		Reference
IIb	1.422 (0.772-2.621)		1.220 (0.659-2.260)		0.942 (0.453-1.957)		0.778 (0.373-1.624)
IIIa	2.007 (1.161-3.471)		1.988 (1.143-3.458)		1.725 (0.953-3.121)		1.609 (0.876-2.956)
IIIb	4.776 (2.851-8.000)		3.977 (2.348-6.737)		3.526 (2.030-6.125)		3.116 (1.749-5.553)
IIIc	7.713 (4.550-13.074)		5.709 (3.299-9.882)		6.234 (3.535-10.993)		4.251 (2.294-7.878)
Tumor size		< 0.001		0.034		0.004		0.638
≤40 mm	Reference		Reference		Reference		Reference
>40 mm	1.987 (1.542-2.560)		1.332 (1.022-1.735)		1.647 (1.176-2.308)		0.913 (0.624-1.336)
Tumor location		0.002		0.596		0.001		0.043
Lower	Reference		Reference		Reference		Reference
Middle	1.307 (0.935-1.827)		1.103 (0.786-1.547)		1.319 (0.795-2.189)		1.313 (0.776-2.221)
Upper	1.209 (0.888-1.647)		1.125 (0.822-1.539)		1.710 (1.117-2.618)		1.819 (1.518-2.857)
Mixed	1.963 (1.396-2.762)		1.279 (0.896-1.825)		2.448 (1.554-3.857)		1.805 (1.052-3.096)
Histologic type		0.344				0.871
Differentiated	Reference		Not included		Reference		Not included
Undifferentiated	1.176 (0.841-1.646)				0.966 (0.635-1.469)
Lymphovascular invasion		0.006		0.832		0.102
No	Reference		Reference		Reference		Not included
Yes	1.422 (1.108-1.825)		1.029 (0.793-1.334)		1.324 (0.945-1.854)
Adjuvant chemotherapy		< 0.001		0.003		0.001		0.022
No	Reference		Reference		Reference		Reference
Yes	0.626 (0.481-0.814)		0.664 (0.508-0.868)		0.551 (0.385-0.787)		0.650 (0.450-0.939)

HR: Hazard ratio; CI: Confidence interval; BPM: Blood parameters.