Tumor-infiltrating platelets predict postoperative recurrence and survival in resectable pancreatic neuroendocrine tumor

Table 3 Univariate Cox regression analyses of overall survival and recurrence-free survival with clinicopathologic characteristics in resectable pancreatic neuroendocrine tumor patients

Factor	OS			RFS
	HR	95%CI	P value	HR	95%CI	P value
Age, < 54/≥ 54	1.790	0.585-5.481	0.308	0.995	0.538-1.840	0.987
Gender, male/female	2.689	0.740-9.770	0.133	0.972	0.526-1.796	0.929
Tumor location, head/body, tail	0.760	0.233-2.482	0.650	1.026	0.531-1.982	0.939
Tumor grade, 1/2	13.403	4.332-41.466	< 0.001	5.509	2.299-13.199	< 0.001
TNM stage, 1, 2/3	8.861	1.960-40.064	0.005	2.892	1.527-5.477	0.001
Functional pNET, no/yes	0.046	0.000-5340.899	0.606	0.412	0.056-3.007	0.382
Platelet count, as × 109/L, < 225/≥ 225	2.497	0.768-8.114	0.128	1.188	0.642-2.201	0.583
MPV in fL, < 11.1/≥ 11.1)	1.442	0.472-4.411	0.521	1.547	0.827-2.893	0.172
PLR, < 130.7/≥ 130.7	1.217	0.409-3.624	0.724	1.043	0.564-1.927	0.894
CD42b expression, negative/positive	6.432	1.425-29.025	0.015	3.203	1.603-6.400	0.001

P < 0.05 was statistically significant. pNET: Pancreatic neuroendocrine tumor; CI: Confidence interval; HR: Hazard ratio; OS: Overall survival; RFS: Recurrence-free survival; MPV: Mean platelet volume; PLR: Platelet lymphoid ratio.