Prebiotic UG1601 mitigates constipation-related events in association with gut microbiota: A randomized placebo-controlled intervention study

Figure 4 Microbial community analysis between responders and non-responders treated with prebiotics. A: Gut microbiome phylum profile of the responder and non-responder groups at baseline and week 4; B: Major microbiome phylum profile at week 4; C and D: Changes in the relative abundance of subordinate taxa (from baseline to week 4); E: Correlations of gut microbiota with serum endotoxemia markers and fecal short chain fatty acids. The abundances of the phylum Firmicutes, the class Clostridia, and the order Clostridiales were reduced in the responders after 4 wk of intervention representing the inverse associations with several fecal short chain fatty acids. Box plots show the 25th and 75th percentiles, median, and range. Outliers are expressed as a small circle (C). ^eP < 0.05. Significantly different from the values at responders, using the Student’s t-test (D). The number in each box indicates coefficient of correlation. The blue color implies a positive correlation, while the red color indicates a negative correlation. Statistically significant correlation is highlighted with a red line (E). CD: Cluster of differentiation; LPS: Lipopolysaccharide; BMI: Body mass index.