Nucleus tractus solitarius mediates hyperalgesia induced by chronic pancreatitis in rats

Figure 6 Administration of 6-cyano-7-nitroquinoxaline-2,3-dione and amino-5-phosphonopentaoic acid into the caudal nucleus tractus solitarius alleviates chronic pancreatitis induced visceral hypersensitivity. A: Schematic diagram of behavioral test; B: A representative section showing the site of cannula implantation within the caudal nucleus tractus solitarius. Bar = 1 mm; C: Microinjection of 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and amino-5-phosphonopentaoic acid (AP-5), instead of saline, increases the abdominal withdraw threshold in chronic pancreatitis rats on postoperative day 14. n = 6 rats in saline and CNQX-treated groups and 7 rats in AP5-treated group, one-way ANOVA, ^cP < 0.001, CNQX or AP5 groups vs saline group. AWT: Abdominal withdraw threshold; CC: Central canal; CNQX: 6-cyano-7-nitroquinoxaline-2,3-dione; AP-5: Amino-5-phosphonopentaoic acid; TNBS: Trinitrobenzene sulfonic acid.