Ultrasound-based techniques for the diagnosis of liver steatosis

Table 2 Quantitative ultrasound: Optimal cutoffs obtained using liver biopsy as the reference standard

Technique	S0 vs S1–S3	S0–S1 vs S2–S3	S0–S2 vs S3
CAP[24,25], dB/m (viral hepatitis)	219-222	233-296	290
	Sensitivity: 76-91%	Sensitivity: 60-87%	Sensitivity: 78%
	Specificity: 52-71%	Specificity: 74-91%	Specificity: 93%
CAP[26-28], dB/m (mixed etiologies)	255-266	283-311	293-318
	Sensitivity: 65-75%	Sensitivity: 57-86%	Sensitivity: 83-88%
	Specificity: 82-87%	Specificity: 85-94%	Specificity: 81-91%
CAP[29], dB/m1 (mixed etiologies)	248	268	280
	Sensitivity: 69%	Sensitivity: 77%	Sensitivity: 88%
	Specificity: 82%	Specificity: 81%	Specificity: 78%
CAP[32], dB/m (NAFLD)	302	331	337
	Sensitivity: 80%	Sensitivity: 70%	Sensitivity: 72%
	Specificity: 83%	Specificity: 76%	Specificity: 63%
ATI[41], dB/cm/MHz (mixed etiologies)	0.63	0.70	0.74
	Sensitivity: 74%	Sensitivity: 86%	Sensitivity: 100%
	Specificity: 77%	Specificity: 81%	Specificity: 82%
UGAP[42], dB/cm/MHz (mixed etiologies)	0.53	0.60	0.65
	Sensitivity: 81%	Sensitivity: 86%	Sensitivity: 84%
	Specificity: 87%	Specificity: 81%	Specificity: 90%
ATT[44], dB/cm/MHz (mixed etiologies)	0.62	0.67	0.73
	Sensitivity: 72%	Sensitivity: 87%	Sensitivity: 82%
	Specificity: 82%	Specificity: 72%	Specificity: 89%

¹Individual patient data meta-analysis. In parentheses: etiology of liver disease. CAP: Controlled attenuation parameter; dB: decibel; ATI: Attenuation imaging; MHz: Megahertz; UGAP: Ultrasound guided attenuation parameter; ATT: Attenuation.