Interplay between post-translational cyclooxygenase-2 modifications and the metabolic and proteomic profile in a colorectal cancer cohort

Figure 5 Proteomic analysis of tumor tissue of colorectal cancer patients and the corresponding non-tumor adjacent tissue. A: Venn diagram with specific and overlapped proteins. 2188 and 4091 proteins were identified (FDR < 1%) in non-tumor and tumor tissue, respectively. Among them, 1573 were identified in both tissues, and 615 and 2518 were unique in non-tumor and tumor tissue, respectively. B: Enrichment analysis of specific proteins identified in tumor tissue by mass spectrometry performed with proteins that were identified with 5 or more peptides (271 most abundant proteins). Most of these proteins had mitochondrial and metabolic function, or were involved in processes related to nucleic acids processing, cytoskeleton, vesicular trafficking, or splicing. C: Specific tumor tissue proteins identified with 15 or more peptides in liquid chromatography-mass spectrometry analyses. T: Tumor; N: Non-tumor; LC/MS: Liquid chromatography-mass spectrometry.