Treatment for gastric ‘indefinite for neoplasm/dysplasia’ lesions based on predictive factors

Table 6 Retrospective prediction rate for the final diagnosis of 24 cases of repeated indefinite for neoplasm/dysplasia by five pathologists in a blinded H and E slide review

	Sex	Age (yr)	Bx N	Original report		Final Dx	Review and Dx rate
				1st Bx	2nd Bx		1st Bx	2nd Bx
1	M	80	2	AGL	AGL	W/D	60%	0%
2	F	78	2	RegA	RegA	Gastritis	100%	100%
3	M	78	2	AGL	AGL	W/D	60%	80%
4	F	76	2	AGL	RegA	W/D	20%	20%
5	M	75	2	AGL	AGL	W/D	80%	20%
6	M	72	2	RegA	AGL	W/D	0%	20%
7	M	72	3	RegA	AGL	W/D	100%	40%
8	M	68	2	AGL	AGL	W/D	100%	100%
9	F	67	2	RegA	AGL	Gastritis	80%	60%
10	M	66	2	RegA	RegA	Adenoma	100%	100%
11	M	66	2	AGL	AGL	Gastritis	60%	40%
12	M	61	3	AGL	AGL	Gastritis	60%	0%
13	M	60	2	AGL	AGL	W/D	0%	80%
14	F	59	2	AGL	AGL	W/D	80%	60%
15	M	59	4	RegA	RegA	Gastritis	100%	40%
16	M	57	3	RegA	RegA	Adenoma	20%	20%
17	M	56	2	AGL	AGL	Adenoma	80%	80%
18	M	56	2	AGL	AGL	W/D	20%	30%
19	M	55	2	RegA	RegA	Gastritis	100%	100%
20	F	54	3	AGL	RegA	W/D	0%	0%
21	M	51	3	AGL	RegA	W/D	0%	0%
22	M	51	3	RegA	RegA	Adenoma	100%	100%
23	M	49	2	RegA	RegA	Gastritis	20%	100%
24	M	42	2	RegA	RegA	Gastritis	80%	80%
Final Dx				1st Bx (A)	2nd Bx (A)	C	κ	P
Gastritis			n = 8	75.0%	60.8%	0.791	0.117	0.463
Adenoma			n = 4	78.3%	84.2%	1.000	0.733	0.001
Adenocarcinoma			n = 12	65.0%	63.3%	0.629	0.415	0.001

H and E: Hematoxylin and eosin; IFND: Indefinite for neoplasm/dysplasia; Bx: Biopsy; Dx: Diagnosis; W/D: Well-differentiated adenocarcinoma; A: Accuracy; C: Concordance; AGL: Atypical epithelium; RegA: Regenerating atypia.