Treatment for gastric ‘indefinite for neoplasm/dysplasia’ lesions based on predictive factors

Table 5 Diagnostic delays in gastric carcinoma and the clinicopathologic correlation n (%)

	Early	Delayed	P	Early	Delayed	P	Early	Delayed	P	Early	Delayed	P
	(≤ 2 wk)	(> 2 wk)		(≤ 2 mo)	(> 2 mo)		(≤ 6 mo)	(> 6 mo)		(≤ 1 yr)	(> 1 yr)
	n = 28	n = 76		n = 73	n = 31		n = 96	n = 8		n = 97	n = 7
Initial Bx			0.109			< 0.001			< 0.001			0.112
RegA	0 (0)	9 (11.8)		1 (1.4)	8 (25.8)		1 (1.4)	8 (25.8)		7 (7.2)	2 (28.6)
AGL	28 (100)	67 (88.2)		72 (98.6)	23 (74.2)		72 (98.6)	23 (74.2)		90 (92.8)	5 (71.4)
Repeated IFND			0.033			0.001			0.048			0.032
No	28 (100)	64 (84.2)		70 (95.9)	22 (71.0)		87 (90.6)	5 (62.5)		88 (90.7)	4 (57.1)
Yes	0 (0)	12 (15.8)		3 (4.1)	9 (29.0)		9 (9.4)	3 (37.5)		9 (9.3)	3 (42.9)
Differentiation			1.000			0.729			1.000			0.554
Differ	25 (89.3)	68 (89.5)		66 (90.4)	27 (87.1)		86 (89.6)	7 (87.5)		87 (89.7)	6 (85.7)
Undiffer	3 (10.7)	8 (10.5)		7 (9.6)	4 (12.9)		10 (10.4)	1 (12.5)		10 (10.3)	1 (14.3)
Tumor size (pathology)			0.252			0.444			0.602			1.000
< 10 mm	6 (24.0)	27 (36.5)		21 (30.9)	12 (38.7)		31 (34.1)	2 (25.0)		31 (33.7)	2 (28.6)
≥ 10 mm	19 (76.0)	47 (63.5)		47 (69.1)	19 (61.3)		60 (65.9)	6 (75.0)		61 (66.3)	5 (71.4)
Invasion depth			0.103			0.395			0.197			0.341
≤ Mucosa	19 (67.9)	62 (82.7)		55 (76.4)	26 (83.9)		73 (76.8)	8 (100)		74 (77.1)	7 (100)
≥ Submucosa	9 (32.1)	13 (17.3)		17 (23.6)	5 (16.1)		22 (23.2)	0 (0)		22 (22.9)	0 (0)
LVI			1.000			0.581			0.278			0.246
No	27 (96.4)	73 (96.1)		71 (97.3)	29 (93.5)		93 (96.9)	7 (87.5)		94 (96.9)	6 (85.7)
Yes	1 (3.6)	3 (3.9)		2 (2.7)	2 (6.5)		3 (3.1)	1 (12.5)		3 (3.1)	1 (14.3)
Complete resection			0.033			1.000			1.000			1.000
No	5 (17.9)	3 (4.0)		6 (8.3)	2 (6.5)		8 (8.4)	0 (0)		8 (8.3)	0 (0)
Yes	23 (82.1)	72 (96.0)		66 (91.7)	29 (93.5)		87 (91.6)	8 (100)		88 (91.7)	7 (100)
Additional surgery			0.031			1.000			1.000			1.000
No	23 (82.1)	73 (96.1)		67 (91.8)	29 (93.5)		88 (91.7)	8 (100)		89 (91.8)	7 (100)
Yes	5(17.9)	3(3.9)		6(8.2)	2(6.5)		8(8.3)	0(0)		8(8.2)	0(0)
Recurrence			0.562			1.000			0.215			0.190
No	28 (100)	73 (96.1)		71 (97.3)	30 (96.8)		94 (97.9)	7 (87.5)		95 (97.9)	6 (85.7)
Yes	0 (0)	3 (3.9)		2 (2.7)	1 (3.2)		2 (2.1)	1 (12.5)		2 (2.1)	1 (14.3)
Endoscopic suspicion for carcinoma			0.003			0.016			1.000			1.000
No	10 (35.7)	52 (68.4)		38 (52.1)	24 (77.4)		57 (59.4)	5 (62.5)		58 (59.8)	4 (57.1)
Yes	18 (64.3)	24 (31.6)		35 (47.9)	7 (22.6)		39 (40.6)	3 (37.5)		39 (40.2)	3 (42.9)

Bx: Biopsy; IFND: Indefinite for neoplasm/dysplasia; LVI: Lymphovascular invasion; AGL: Atypical epithelium; RegA: Regenerating atypia; Differ: Differentiated adenocarcinoma; Undiffer: Un-differentiated adenocarcinoma.